**Acknowledgements**

This research was supported in part by the Canary Islands Government through the ACIISI (Canarian Agency for Research, Innovation and the Information Society), ITHACA project under Grant Agreement ProID2017010164 and by the Spanish Government through PLATINO project (TEC2017-86722-C4-4-R). This research was supported in part by the Cancer Prevention and Research Institute of Texas (CPRIT) grant RP190588 and the U.S. National Institutes of Health (NIH) grants (R01CA156775, R01CA204254, R01HL140325, and R21CA231911). This work was completed while Samuel Ortega was beneficiary of a pre-doctoral grant given by the "*Agencia Canaria de Investigacion, Innovacion y Sociedad de la Información (ACIISI)*" of the "*Conserjería de Economía, Industria, Comercio y Conocimiento*" of the "*Gobierno de Canarias,*" which is part-financed by the European Social Fund (FSE) (*POC 2014-2020, Eje 3 Tema Prioritario 74 (85%)*).
