**5. Conclusions**

Researcher aims to design or synthesise a molecule with multidirectional use, for developing such a molecule endless work is needed with clarity of innovation leading to novelty. Salen is among those important creation, nevertheless molecule has unimaginable and multiple scope of application ranging from catalysis to biological activities, or as therapeutic use in many medicinal drugs. Salen and its derivatives have been extensively studied because the structural configuration of complex felicitates its importance in various chemical reactions. Widespread use enhances its reliability as catalyst in oxidation, reduction, asymmetric synthesis and many more. The nonsymmetrical salen derivatives have signify to be essential for the preparation of different polymer-supported catalysts that show improved properties (higher activities, catalyst recycling) as collate with parent mono-nuclear complexes. Metallic interference adhere tremendous approach in chemical reaction, presence of metallic centres promotes many specific reaction. Henry reaction, Mannich reaction, Diels-Alder reaction, alkene epoxidation and many such reactions encountered frequently employing salen as transitional part between reactant and product. Metal organic framework (MOF) using salen ligand is recent advancement in the field of macromolecule i.e., supramolecular structure attracting great attention in the field of catalysis and material science. Thus, it is assumed that in near future salen can escort a bloom in the field of catalysis, magnetism, sensors, medicinal areas and material sciences.

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**Author details**

Ashish K. Asatkar1

India

India

\*, Mamta Tripathi2

\*Address all correspondence to: ashu.asatkar@gmail.com

provided the original work is properly cited.

and Deepali Asatkar3

1 Department of Chemistry, Government Gundadhur P.G. College, Kondagaon, CG,

2 School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur, CG,

© 2020 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium,

3 Department of Chemistry, Rani Durgavati University, Jabalpur, MP, India

*Salen and Related Ligands*

*DOI: http://dx.doi.org/10.5772/intechopen.88593*

*Salen and Related Ligands DOI: http://dx.doi.org/10.5772/intechopen.88593*

*Stability and Applications of Coordination Compounds*

found in cis-platin [129, 130].

**4.5 Sensors**

**5. Conclusions**

P-450 mimics [123], vitamin B12 [124, 125]. Metallosalens are capable of inducing specific damage to DNA or RNA and have been recommended as footprinting agents [126, 127]. Salen complexes are versatile (biomimetic) catalysts for important organic transformations. Derivatives of diaryl-substituted amines linked with metal attached with salen as ligand were experimented in number of cancerous cell lines [128]. Aromatic ring substitution and structural orientation of salen complexes predict the cytotoxicity. Two labile titanium-salen complexes of *cis* configuration were discovered as antitumor agents due to its chelating ability as

Metal salen complexes have shown the sensory properties for verities of metal ions and small molecules [2, 38]. Colorimetric and fluoremetric both types of responses have been observed depending on the sensor and sensing ions. Chan et al. reported the Pt(II)-salphen based polymeric sensors for the detection of Pd(II), Cd(II), Hg(II), Zn(II), Mg(II), Ca(II), Li(I) and K(I) ions [131, 132]. Wezenberg et al. reported Zn(II)-salphen complexes as metal ion sensors based on demetalation of complexes [133, 134]. Many multimetallic salen complexes have found to be potential sensory properties [2]. Song et al. reported chiral salen based fluorescent polymeric sensor for the enantioselective detection of α-hydroxy carboxylic acids showing fluorescence quenching upon reaction [135]. The same group reported another chiral salen based fluorescent polymeric sensor for the detection of Zn(II) ion as turn-on fluorescence response [136]. Salen based chemosensors for the detection of Al(III)

ion based on transmetalation mechanism have also been reported [137].

Researcher aims to design or synthesise a molecule with multidirectional use, for developing such a molecule endless work is needed with clarity of innovation leading to novelty. Salen is among those important creation, nevertheless molecule has unimaginable and multiple scope of application ranging from catalysis to biological activities, or as therapeutic use in many medicinal drugs. Salen and its derivatives have been extensively studied because the structural configuration of complex felicitates its importance in various chemical reactions. Widespread use enhances its reliability as catalyst in oxidation, reduction, asymmetric synthesis and many more. The nonsymmetrical salen derivatives have signify to be essential for the preparation of different polymer-supported catalysts that show improved properties (higher activities, catalyst recycling) as collate with parent mono-nuclear complexes. Metallic interference adhere tremendous approach in chemical reaction, presence of metallic centres promotes many specific reaction. Henry reaction, Mannich reaction, Diels-Alder reaction, alkene epoxidation and many such reactions encountered frequently employing salen as transitional part between reactant and product. Metal organic framework (MOF) using salen ligand is recent advancement in the field of macromolecule i.e., supramolecular structure attracting great attention in the field of catalysis and material science. Thus, it is assumed that in near future salen can escort a bloom in the field of catalysis, magnetism, sensors,

**108**

medicinal areas and material sciences.
