**14.1 Genomic alterations low grade glioma**


Children having mutation in one of two tuberous sclerosis genes (*TSC1*/ hamartin or *TSC2*/tuberin) are at a risk of developing Subependymal giant cell astrocytomas, cortical tubers, and subependymal nodules, as either of these mutations results in activation of the mammalian target of rapamycin (mTOR) complex 1 [34].
