**Abstract**

Biomarkers are emerging research filed in the past decade. Even though numerous biomarkers were reported, the efficiency of cancer therapy remains low. So the question emerges as to how much can we trust the current biomarkers on cancer therapy? In this upcoming chapter, we would like to illustrate the outcomes of classical cancer therapies on advanced pancreatic cancer disclosed successful, neutral and failed in clinical trials. The analysis will be carried on the perspective interdisciplinary on the biomarkers including anatomy, physiology, pharmacology, biochemistry, history path and development of pharmacy. Particular in-depth insight may open a window for new researches and lighting the therapies.

**Keywords:** advanced pancreatic cancer, biomarker, clinical trials

## **1. Introduction**

Advance pancreatic cancer (APC) is a highly lethal tumor. Most patients with APC remain asymptomatic until the disease reaches an advanced stage [1]. The incidence rate was 5.5 for men and 4.0 for women per 100,000 people. The mortality rate was 5.1 for men and 3.8 for women per 100,000 people around the world, according to data, from 2018 [2]. For the incidence rate, Asia is at 48.4%, Europe at 23.4%, and the Americas is at 21.0%. As for the mortality rate, Asia is at 57.3%, Europe at 20.3%, and the Americas is at 14.3% [3].

Our previous study disclosed that there were more than 19 chemotherapy regimens combinations in clinical practice available [4]. The advantages and disadvantages of each therapy regimens are clear. Briefly, to lengthen the overall survival and to reduce the treatment-related toxicity we must consider the outclass selection. There are more than 14 treatment-related toxicities in gastrointestinal, constitutional, skin, hepatotoxicity, infection, vascular, neuropathy, mental, pain, renal, electrolytes and pulmonary of human body in current dominant chemotherapy regimens. To broaden the balance requires expertise and professional medical training based on evidence.
