**5.2 Estimation of clinical trials with the neutral outcome on advanced pancreatic cancer**

Here are three studies clarified neural results in OS and PFS result, ranged from 2008 to 2016, totally recruited 229 APC patients (121 male and 108 female). For details please see **Table 3**. Averagely the OS is 16.6 months and PFS is 9 months in neutral studies. For example, Jean in 2008 reported gemcitabine plus AG-013736 achieved better OS and PFS (6.9 and 4.2) than gemcitabine single used.
