**Acknowledgements**

This work was supported by the Chengdu Medical College Natural Science Foundation (CYZ18-08, CYZ18-20, CYZ18-33), the Sichuan Provincial Education Department (17ZA0134), the Sichuan Medical Association (S18023), and Sichuan undergraduate innovation and startup program funding support (S201913705080, S201913705130, S201913705059).
