**5.3 Estimation of clinical trials with the failed outcome on advanced pancreatic cancer**

Regarding the failed outcomes, there are 14 studies ranged from 2011 to 2018, recruited 2448 APC patients (1385 male and 1063 female) for clinical trials. For details please see **Table 1**. Averagely the OS is 8.25 months and PFS is 4.39 months. It is evident that Faivre et al. in 2016 tested sunitinib malate to treat APC and achieved 38.6 months of OS and 12.6 months of PFS. However, Brian reported that hydroxychloroquine cures APC, unfortunately, there were 1.8 months both in OS and PFS negativity. Even though many combination tests, the benefit for APC patient is low.
