**Author details**

In another study, there is downregulation of miR-200 family in ovarian cancer. The direct target of miR-200 is zinc finger E-box-binding homeobox 1 and 2 (ZEB1 and ZEB2). It prevents the EMT, metastasis, invasion, and migration of tumor cell. Interleukin-8 and CXCL1 (released from tumor epithelial cells) are also the target of

**Sr. no. MicroRNAs Potential targets Function Ref.** 1 miR-214 PTEN Antiapoptosis [172] 2 Hsa-miR-182 FOXO3 and FOXO1 Increased proliferation and growth [173]

**Sr. no. MicroRNAs Potential targets Function Ref.**

migration

Inhibition of cell invasion and migration and proliferation; initiates the senescence

[174]

[175]

1 miR-200 ZEB1 and ZEB2 Prevent the EMT, metastasis, invasion, and

In another study there is downregulation of miR-506 in ovarian cancer, so there is cell migration invasion of the cancer cell. When this miRNA is overexpressed, it causes the expression of E-cadherin and results in inhibition of cell invasion and migration and proliferation of ovarian cancer and, via targeting SNAI2 (E-cadherin transcriptional factor), prevents the EMT induction by *TGF-β* (**Table 27**). The miR-506 directly targets the CDK4/CDK6-FOXM1 axis and initiates the senescence

MicroRNAs (miRNAs) could be used as potential tool for early detection of cancer. It may upregulate or downregulate multiple targets through various mechanisms. It is upregulated as an oncogene (miRNA) and downregulated as a tumor suppressor. microRNA targets the PTEN, interferon (tumor suppressor genes), and

miR-200 and prevent the angiogenesis of tumor cell [174].

CDK6-FOXM1 axis

[175].

**24**

**Figure 17.**

**Table 26.**

**Table 27.**

*miRNA and ovarian cancer.*

*Current Cancer Treatment*

*MicroRNAs activating the ovarian cancer.*

2 miR-506 SNAI2, CDK4/

*MicroRNAs suppressing the ovarian cancer.*

**6. Conclusion**

Ayesha Siddiqua<sup>1</sup> , Sumaira Kousar1,2\*, Amer Jamil1 , Riaz Tabassum<sup>1</sup> , Tariq Mehmood<sup>1</sup> and Nusrat Shafiq2

1 Department of Biochemistry, University of Agriculture, Faisalabad, Pakistan

2 Department of Biochemistry, Government College Women University, Faisalabad, Pakistan

\*Address all correspondence to: sumairakausar@gcwuf.edu.pk

© 2020 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
