Meet the editor

Dr Zhengchao Wang is a full professor at the College of Life Sciences, Fujian Normal University (China). He is a Principal Investigator for General Program for National Natural Science Foundation of China and Program for New Century Excellent Talents in University of Ministry of Education of China. He is also a team leader in the Fujian Provincial Key Laboratory for Developmental Biology and Neurosciences, Key Laboratory of

Optoelectronic Science and Technology for Medicine of Ministry of Education. He obtained his PhD in 2008 and has a long teaching and research career. He has published 161 scientific papers in English or Chinese, participated in approximately 30 grants, and published 11 books as the editor in his specialty and related diseases.

Contents

**Section 1**

Clinical Features of PCOS

*by Maria Mitkova Orbetzova*

of Polycystic Ovary Syndrome

*by Bassim Alsadi*

Ovary Syndrome

Dysfunction (PCO)

**Section 2**

**Preface III**

Clinical Features of Polycystic Ovarian Syndrome **1**

**Chapter 1 3**

**Chapter 2 17**

**Chapter 3 47**

**Chapter 4 63**

Basic Researches of Polycystic Ovary Syndrome **71**

**Chapter 5 73**

**Chapter 6 85**

**Chapter 7 95**

Clinical Impact of Insulin Resistance in Women with Polycystic

Effects of Exercise Intervention on the Improvement

Effect of Aromatase Inhibitors versus Clomiphene Citrate for Ovulation Induction in Infertile Women with Ovulatory

*by Hassan S.O. Abduljabbar, Magda Hagras and Rania Magadmy*

Endocrine Characteristics and Regulatory Mechanism of Follicular

*by Zhenghong Zhang, Yan Zhang, Fengping Lin and Zhengchao Wang*

Development and Ovulation Failure in Mammalian Ovary

Expression and Contribution of Insulin Signaling Pathway

*by Qingqiang Lin, Hong Zhang, Jiuhua Zhao and Zhengchao Wang*

Roles of ncRNAs in Ovarian Dysfunction of Polycystic Ovary Syndrome

to the Development of Polycystic Ovary Syndrome

*by Junyong Han, Zhen Yu, Gang Chen and Fan Wang*

*by Shaobing Wang, Zhenghong Zhang and Yiping Liu*

## Contents


#### **Chapter 8 105**

Interplay between Oxidative Stress and Chronic Inflammation in PCOS: The Role of Genetic Variability in PCOS Risk and Treatment Responses *by Rok Herman, Mojca Jensterle Sever, Andrej Janež and Vita Dolžan*

#### **Chapter 9 125**

Computational Systems Analysis on Polycystic Ovarian Syndrome (PCOS) *by Nor Afiqah-Aleng and Zeti-Azura Mohamed-Hussein*

Preface

Polycystic ovary syndrome (PCOS) is a major health problem with a heterogeneous hormone-imbalance disorder that occurs in approximately 4~18% of reproductiveaged women worldwide, which is characterized by hyperandrogenism, ovulatory

PCOS is affected by various factors and there are no unique diagnostic criteria in different regions, due to the heterogeneity of clinical manifestations and endocrine system changes of PCOS. Therefore, it is often difficult to accurately diagnose women with PCOS, as the signs and symptoms of PCOS can vary among individuals. Although PCOS is usually diagnosed during the early reproductive years, the precise pathogenesis of PCOS remains unclear. An increasing number of studies have demonstrated that the insulin signaling pathway has an important role in the pathophysiology of PCOS, including phosphatidylinositol 3-kinase and protein kinase B signaling, which is critically implicated in insulin resistance, androgen secretion, obesity, and follicular development. PCOS manifests as defective ovarian steroid biosynthesis and hyperandrogenemia, and 50~70% of women with PCOS exhibit insulin resistance and are hyperinsulinemic, indicating that insulin resistance and hyperinsulinism may have an important role in the

This book intends to provide the reader with a comprehensive overview of the latest PCOS research and to benefit the population of women with PCOS. At last, it is my hope that this book is meaningful to the clinicians who care for women with PCOS

Provincial Key Laboratory for Developmental Biology and Neurosciences,

**Dr. Zhengchao Wang**

College of Life Sciences, Fujian Normal University,

Fuzhou, China

and to the researchers who investigate the complexities of this disorder.

process dysfunction, and polycystic ovaries.

pathophysiology of PCOS.
