**5. Conclusions**

There are many physiological and pathophysiological changes associated with ageing that can affect the disposition of a drug. However, there are many variations among individuals. Thus, health professionals should be more alert during a prescription to older patients and monitor their health status with individual attention.

One of the main factors responsible for variability in older patients is genetics since the structure, function and expression of most of the enzymes involved in metabolism can be affected due to genetic polymorphism, which will modify the therapeutic effect of certain drugs. Thus, the concept of individualized therapy, which analyses for each subject, genetic and non-genetic factors to optimize the treatment for each patient according to their characteristics, is increasingly common.

In general, older patients have a higher sensitivity to drug therapy, so recommendations for the appropriate prescription of drugs in the elderly population should be considered.

The incorporation of the described criteria in the CDSS has been successful in the detection of PIM. Persistent changes in medication were recorded in 8.7% of the alerts generated [48]. These data suggest that CDSS alerts are a useful tool for implementing guidelines related to the identification of PIM for older patients and for helping physicians during the prescription process, improving healthcare practices.
