**3.1 Blood count**

In peripheral blood of patients with CML, there is a leukocytosis of approximately 225,000/mm3 ranging from 20,000 to 600,000/mm3 and an intense increase in circulation granulocytes. Granulocytosis is characterized by a small proportion of leukemic blasts and promyelocytes and predominance of intermediate forms (such as myelocytes and metamyelocytes), in addition to maturing and fully mature neutrophils (rods and segmented). Differential leukocyte count shows staggered left shift from mature neutrophils to myeloblasts. Fifteen to 20% proportions of basophils may be found [1, 37].

The presence of mild anemia and thrombocytosis are also common in CML. There is a small correlation between hemoglobin concentration and the total number of white blood cells (hemoglobin values range from 9.7 g/dL ranging from 5.4 to 14.4 g/ dL). Depending on the stage of the disease, the number of platelets ranges from 485,000/mm3 , ranging from 25,000 to 1,400,000/mm3 . Basophilia and eosinophilia are common findings. Leukocyte alkaline phosphatase is generally low and can be used to distinguish CML from other myeloproliferative diseases [1, 37, 38].

### **3.2 Myelogram**

Analysis of bone marrow (BM) through myelogram reveals granulocytic hyperplasia, leading to a leukoerythroblastic ratio of 20:1. The differentiation sequence is maintained, however with a predominance of younger cells such as promyelocytes

and myelocytes. The number of megakaryocytes is increased. Other nonspecific biopsy findings include reticulin fibrosis and vascularization [1, 37].
