**5. Therapeutic approach and outlooks**

CADASIL is one of the most monogenic causes of stroke. No disease-modifying treatment is available. Being a genetic disease, two possible gene therapeutic approaches have been highlighted [85, 86], but, to date, only a symptomatic therapy focused on mitigating symptoms and management of the patient's vascular risk factor can be applied [87, 88], beginning as immediate action to promote healthy individual behaviors, i.e., to refrain from smoking. Anyway, it is important that patients be referred to multidisciplinary and specialized centers, not only providing genetic counseling but also integrating the clinical and neuroimaging follow-up with neuropsychiatric, psychologic, and physical rehabilitation consultations.

*Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy… DOI: http://dx.doi.org/10.5772/intechopen.87248*
