**6. Conclusion**

CML is a special disease with a milestone history and remarkable nonstopping genetic discoveries, which have paved the path in effective treatment of CML by translating findings into clinical settings.

It is believed that the continuing study on genetic variations will help to develop TKI therapy to minimize further therapy resistance in the future.

CML is an old disease with new face. The continuous discoveries of genetic variations and multiway translocation of Ph chromosome in CML will help in the diagnosis and monitoring of treatment.

The mystery and the associations of the combination of CML and CLL in some reported cases are still unknown.

Such fascinating stories made the best example in the process of conquering the human diseases.

## **Author details**

Zhan He Wu Western Sydney Genome Diagnostics, The Children's Hospital at Westmead, Affiliated to University of Sydney, Sydney, Australia

\*Address all correspondence to: zhan.wu@health.nsw.gov.au

© 2020 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
