**2. Conclusion**

The disorders described above highlight the importance of the identification and diagnosis of monogenic hereditary hypertension. The gold standard for the diagnosis of monogenic forms of hypertension is gene detection. It attaches great significance to carry out gene detection for patients with hypertension who are clinically suspected.

Genetic testing can not only screen pathogenic genes to guide targeted therapy, but also screen the genes of the proband's family to detect all individuals carrying pathogenic genes, which is conducive to early detection, early treatment, and prenatal diagnosis of the disease.

Meanwhile, monogenic hypertension is a hereditary rare disease with relatively definite genes. The study on its genetic mechanism has greatly extended the understanding about the pathologic molecular mechanism of hypertension, which will help us to learn the correlation between hypertension and heredity more deeply.

#### **Acknowledgements**

We thank Dr Yue Liu and Dr Wenjia Chen for their efforts on the article topic selecting, and Jiaxing Sun for the modifying English language. This article was supported by the National Natural Science Foundation of China (Grant No. 81700318 and 81570437).
