**4.7 X-linked thrombocytopenia and X-linked neutropenia**

XLT is assumed as congenital thrombocytopenia that is sometimes intermittent (IXLT). In such cases, the eczema is usually mild. Generally, XLT patients have got a benign disease as well as excellent survival in contrast to patients with WAS. serious hemorrhage in 13.9%, life-threatening infections in 6.9%, autoimmunity in 12.1%, and malignancy in 5.2% of XLT patients at median ages of 4.9 years, 24.8 years, 12.2 years, and 34.0 years, respectively. Every male with thrombocytopenia and small platelets should be evaluated for WASp expression and WAS gene mutations [25].

XLN presents mainly as a congenital and severe form of neutropenia. Unlike WAS, infectious complications due to T-cell immunodeficiency are absent. Impairments in immune function are similar to those explained for WAS. Nevertheless, Decreased NK cell count is a valid finding in XLN patients. Also, a slight decrease in platelet count has been reported. The potential risk of myelodysplastic syndrome and chronic myelocytic leukemia exists, which needs regular surveillance [26].
