**Author details**

Diane Irvine Duncan Private Practice, Fort Collins, Colorado, USA

\*Address all correspondence to: momsurg@aol.com

© 2020 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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*Combining PDO Threads with Exosomes for Microlifting DOI: http://dx.doi.org/10.5772/intechopen.91796*

> [8] Poe AJ, Knowlton AA. Exosomes as agents of change in the cardiovascular system. Journal of Molecular and Cellular Cardiology. 2017;**111**:40-50. DOI: 10.1016/j.yjmcc.2017.08.002

[9] Shabbir A, Cox A, et al. Mesenchymal cell exosomes include proliferation and migration of normal and chronic wound fibroblasts, and enhance angiogenesis in vitro. Stem Cells and Development. 2015;**24**(14):1635-1647. DOI: 10.1089/scd. 2014.0316. [Epub:

[10] van Balkom BW, de Jong OG, Smits M, Brummelman J, den Ouden K, de Bree PM, et al. Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells. Blood. 2013;**121**:

[11] Rashed MH, Bayraktar E, Helal G, et al. Exosomes: From garbage bins to promising therapeutic targets. International Journal of Molecular Sciences. 2017;**18**(3):538. DOI: 10.3390/ ijms18030538. PMCID: PMC5372554

[12] Hu L, Wang J, Zhou X, et al. Exosomes derived from human adipose mesenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts. Scientific Reports. 2016;**6**:32993. DOI: 10.1038/srep32993.

PMCID: PMC5018733

[13] https://www.fda.gov/ vaccines-blood-biologics/safetyavailability-biologics/public-safetynotification-exosome-products [Accessed: 20 December 2019]

[14] https://www.fda.gov/

regulatory-information/search-fdaguidance-documents/regulatoryconsiderations-microneedling-devices

[Accessed: 21 September 2018]

13 April 2015]

3997-4006; S1-S15

[1] Knoepfler PS. Deconstructing stem cell tumorigenicity: A roadmap to safe regenerative medicine. Stem Cells. 2009;**27**(5):1050-1056. DOI: 10.1002/ stem.37. PMCID: PMC2733374

[2] Gurunathan S et al. Review of the isolation, characterization, biological function, and multifarious therapeutic approaches of exosomes. Cell. 2019;**8**(4):307. DOI: 10.3390/ cells8040307. PMCID: PMC6523673

[3] De Almeida AT, Figuerdo V, et al. Consensus recommendations for the use of hyperdiluted calcium hydroxyapatite (Radiesse) as a face and body biostimulatory agent. Plastic and Reconstructive Surgery. Global Open. 2019;**7**(3):e2160. DOI: 10.1097/ GOX.0000000000002160. PMCID:

[4] Amselem M. Radiesse®: A novel rejuvenation treatment for the upper arms. Clinical, Cosmetic and Investigational Dermatology. 2016;**9**: 9-14. DOI: 10.2147/CCID.S93137.

[5] Mitchell R, Mellows B, Sheard J, et al. Secretome of adipose-derived mesenchymal stem cells promotes skeletal muscle regeneration through synergistic action of extracellular vesicle cargo and soluble proteins. Stem Cell Research & Therapy. 2019;**10**:116. DOI: 10.1186/s13287-019-1213-1. PMCID:

[6] Ferraris V. How do cells talk to each other? Paracrine factors secreted by mesenchymal stromal cells. The Journal of Thoracic and Cardiovascular Surgery. 2016;**151**(3):849-851. DOI: 10.1016/j.jtcvs. 2015.11.035. [Epub: 27 November 2015]

[7] Rustom A, Saffrich R, Markovic I, Walther P, Gerdes HH. Nanotubular highways for intercellular organelle transport. Science. 2004;**303**:1007-1010

**References**

PMC6467620

PMC6451311

PMCID: PMC4699473

*Combining PDO Threads with Exosomes for Microlifting DOI: http://dx.doi.org/10.5772/intechopen.91796*
