**6.1 Primaquine and tefenoquine for radical treatment**

Primaquine – an 8-aminoquinoline is used for radical cure. In case of *P. vivax* 15 mg per day for 14 days and for *P. falciparum* a single dose of 45 mg is administered for eliminating hypnozoites for the former and gametocytes for the later, respectively. Recently tefenoquine, another 8-aminoquioline, has been recommended. But both of these drugs may cause possible hemolysis in G6PD-deficient patients [21]. Attempts are being made to find newer molecules to address this issue. In this regard, Medicines for Malaria Venture (MMV) is playing a primary role [22].
