*2.4.3 Obinutuzumab*

Obinutuzumab is a novel humanized type II glycoengineered anti-CD20 antibody [126]. In vitro studies have shown that obinutuzumab may induce superior B cell cytotoxicity as compared to rituximab in patients with SLE [126]. Obinutuzumab is considered an alternative B-cell depleting agent for the treatment of SLE [127]. It has been suggested that SLE patients with secondary non-response to rituximab should be preferentially switched to another B-cell depleting agent instead of belimumab [128].
