*8.2.5 Cyclosporine and tacrolimus*

Both cyclosporine (CSA) and tacrolimus are calcineurin inhibitors used as maintenance drugs and steroid-sparing agents, in patients with moderate to severe SLE [60]. CSA is considered safe in pregnancy, but blood pressure and renal function should be closely monitored [20]. It is recommended that CSA and tacrolimus should only be used when maternal benefit outweighs fetal risk, and preferably at minimum doses [63].
