*2.4.6 Sifalimumab*

Interferons (IFNs) are a family of potent immunostimulatory cytokines that are broadly divided into three subtypes, type I, type II and type III [135]. Of all the type I IFNs, IFNα is the most abundant and is well characterized. The role of interferons in autoimmunity, especially SLE is discussed [136]. Sifalimumab is a fully human monoclonal antibody against multiple IFN-α subtypes and has shown promise in a phase IIb clinical trial in SLE [137].
