**4.3** *Enterobacterales*

*Escherichia coli* and *Klebsiella pneumoniae* are of the most important pathogens in humans involved in different community and nosocomial infections, including bloodstream infections, urinary tract infections, intraabdominal infections and pneumonia [86–89]. The success of *E. coli* and *K. pneumoniae* as a community and nosocomial pathogens is attributed to their resistance to several antibiotic categories [86, 90]. Similar to *P. aeruginosa* the repurposing drugs developed today for *E. coli* and *K. pneumoniae* are in the preclinical and clinical stages of development.
