**Acknowledgements**

Dr. John Robert Paterson (1955–2004), our dear friend who initiated and steered this line of research, always—from schooldays onwards—thought of himself as a chemist first and foremost. Through his long and arduous training in pharmacy, medicinal chemistry, medicine, royal college membership and clinical biochemistry he described himself as a chemist. Most of the work summarised herein, including results published after his death, was either planned by him or arose from discussions during his life. Our prime purpose in undertaking this compilation has been to remain true to his vision. We only pray that there are no glaring chemical errors the fault is entirely ours if there are.

We are grateful to Hannah Mortlock for the preparation of **Figure 1**.

## **Conflict of interest**

The authors declare no conflict of interest.

#### **Thanks**

We wish to thank Dumfries and Galloway Health Board for their support over the many years of these studies, especially their Research and Development and Library services.

Our work has been supported financially by the Dumfries and Galloway Health Board's Salicylic Acid Research Endowment Fund.

**Author details**

† Deceased.

**191**

Cargenbridge, Dumfries, Scotland

*Salicylic Acid Sans Aspirin in Animals and Man DOI: http://dx.doi.org/10.5772/intechopen.91706*

provided the original work is properly cited.

\*Address all correspondence to: jim.lawrence@nhs.net

James Ronald Lawrence\*, Gwendoline Joan Baxter and John Robert Paterson† Research and Development Support Unit, Dumfries and Galloway Royal Infirmary,

© 2020 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium,

### **Other declarations**

We have done our utmost to accurately reflect the findings and conclusions of the many authors quoted in Section 5. Profuse apologies if our reflections on their studies appear at variance with their interpretations.

*Salicylic Acid Sans Aspirin in Animals and Man DOI: http://dx.doi.org/10.5772/intechopen.91706*

*oligomer/monomer transformation permits nuclear translocation of a cytosolic messenger*

of ASA as a biomarker of oxidative "stress" in man—see Section 2.

*Drug Repurposing - Hypothesis, Molecular Aspects and Therapeutic Applications*

Re-focus on the importance of the SA moiety of ASA should also lead to further evaluation of SA derivatives which are more active than SA itself in interaction with particular "binding protein/receptors" [47, 48]. At a more basic level we have previously pointed out that, particularly to extend its use in prophylaxis, the risk/ benefit profile of ASA may be improved with an SA/ASA combined formulation [54]. Given what we have learned on this investigative journey it is somewhat paradoxical that we embarked upon it driven by desire to capitalise on the hydroxylation

Dr. John Robert Paterson (1955–2004), our dear friend who initiated and steered this line of research, always—from schooldays onwards—thought of himself as a chemist first and foremost. Through his long and arduous training in pharmacy, medicinal chemistry, medicine, royal college membership and clinical biochemistry he described himself as a chemist. Most of the work summarised herein, including results published after his death, was either planned by him or arose from discussions during his life. Our prime purpose in undertaking this compilation has been to remain true to his vision. We only pray that there are no glaring chemical errors—

We are grateful to Hannah Mortlock for the preparation of **Figure 1**.

We wish to thank Dumfries and Galloway Health Board for their support over the many years of these studies, especially their Research and Development and

Our work has been supported financially by the Dumfries and Galloway Health

We have done our utmost to accurately reflect the findings and conclusions of the many authors quoted in Section 5. Profuse apologies if our reflections on their

*to activate immune-associated genes* [40]*.*

**Acknowledgements**

**Conflict of interest**

**Thanks**

**190**

Library services.

**Other declarations**

the fault is entirely ours if there are.

The authors declare no conflict of interest.

Board's Salicylic Acid Research Endowment Fund.

studies appear at variance with their interpretations.
