**5. Conclusion**

Drug repositioning is a useful research strategy to identify the therapeutic agents for glioma. Here, we discuss the current drug repositioning and its perspective for glioma treatment. Despite many efforts to date, no agents are widely used in the current clinical practice. For breaking down the current situation, appropriate screening system, suitable animal model, well-designed clinical trials, and tight collaboration with pharmaceutical companies are warranted. From now on, the drastic progress in this field would be occurred by new methods including AI.
