**3.1 Various anti-cancer targets that can be used for repurposing of drug**

Based on global statistics, more than 20 million individuals will be detected with cancer in 2025. Certain cancer like breast cancer, colorectal, prostate is mostly remaining incurable in advanced stages with existing treatment and that leads to increase in number of cases. Thus, addressing these present and future challenges requires more effective cancer drugs [29]. Traditional anti-cancer therapy like Chemotherapy and radiation have dangerous side effects that range from bone marrow suppression, oral mucositis, arising of secondary cancer to vomiting, diarrhea and organ specific toxicity that drastically decrease the quality life and overall survival of cancer patients [30]. From this point of view, drug repositioning option is promising strategy to identify non-cancer drugs like aspirin and chlorpromazine which have anti-tumor activity with less side effects comparable to traditional anti-cancer drugs. Traditionally limited targets were identified for anti-cancer drugs that involve cell cycle inhibitors, anti-metabolites, anti-angiogenesis, growth factor inhibitors, pro-apoptotic. But today many new targets identified that work in more specific way and reduce dangerous side effects of anti-cancers. Some novel drug target mentioned in following diagram that might be work well for future drug repurposing in oncotherapeutics (**Figure 3**).

**Figure 3.** *Hall marks of cancer.*
