**1. Introduction**

In 1859, Hermann Kolbe was paved the foundation for the development of Aspirin moiety for clinical practice. Whilst, there were no scientific resemblance established for aspirin as medicine [1]. After a long laboratory modification Felix Hoffman had succeeded to evolve the finest, clinical molecule by means of acetylation. Clinical investigation had passed the salicylate compound with intended therapeutic effects with no or minimum side effect. Clinicians had accepted this molecule open handedly. On February 1, 1899 Aspirin is registered as an authentic molecule (**Figure 1**) [2]. Currently, aspirin has become renowned and huge blockbuster molecule as NSAIDs followed by primary prevention of CVD [3].
