*4.3.2 Anthelmintic drugs*

Four anthelmintic drugs, niclosamide, oxyclozanide, rafoxanide and ivermectin were shown to present synergy with colistin against Col-R *K. pneumoniae* [30, 46–48, 57]. Compared to Col-R isolates of *A. baumannii* and *P. aeruginosa* much lesser effect has been observed regarding the effect of these drugs in combination with colistin against Col-R isolates of *K. pneumoniae*. Additionally, in the murine model of peritoneal sepsis model by Col-R clinical isolate of *K. pneumoniae*, rafoxanide in monotherapy and in combination with CMS compared with control animals and with CMS alone, increased mouse survival to 50 and 67%, and reduced bacterial loads in tissues and blood between 2.5 and 3 log10cfu/g or mL, and 2 and 3 log10cfu/g or mL, respectively [47].
