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## Meet the editors

Raquel Franco Leal is Associate Professor at the Department of Surgery, Colorectal Surgery Unit, School of Medical Sciences, University of Campinas (UNICAMP). She has graduated in Medical Sciences, specialized in General Surgery and Coloproctology, and received her MSc and PhD degree at the University of Campinas. She was a Postdoctoral fellow at the University of Chicago and at the Institut D'Investigacions August Pi I Sunyer

Biomèdiques, Hospital Clínic of Barcelona. She is member of the Brazilian Society of Coloproctology and the International Society of University Colon and Rectal Surgeons (ISUCRS), an honorary member of the Brazilian Association of Ulcerative Colitis and Crohn's Disease (ABCD), and a member of the Study Group of Inflammatory Bowel Disease in Brazil (GEDIIB), the European Crohn's and Colitis Organisation (ECCO), and the Pan American Crohn's Colitis Organisation (PANC-CO). As a researcher she has been devoted to biomedical science and in particular to the study of inflammatory bowel diseases for over 14 years. Dr Franco Leal is the Coordinator of the Inflammatory Bowel Disease (IBD) Research Laboratory at the UNICAMP, developing basic and clinical research on IBD.

Tristan Guillermo Torriani, Ph.D. is Assistant Professor at the School of Applied Sciences, Limeira Campus, University of Campinas, Brazil. He has published several research articles in History of Science and Ideas, translations, and has extensive experience in academic English, having provided English editing services for more than 20 articles in the field of Gastroenterology. His qualifications include the Cambridge English Proficiency

Exam (CPE), the British Council Researcher Connect Course, and a specialized course in Teaching Academic English Writing at the University of Bath, England.

Contents

**Section 1**

**Section 2**

**Section 3**

Bowel Disease

*and Caio Almeida Perez*

*by Dolores Ortiz-Masià*

*and João José Fagundes*

*by Giovanna Rosa Degasperi*

*by Martina Perše and Ana Unkovič*

Therapies for Inflammatory Bowel Diseases

*Jefferson Luiz da Silva and Murillo Duarte-Silva*

**Preface III**

Immunopathological Aspects **1**

**Chapter 1 3**

**Chapter 2 23**

Immunosuppressor and Corticosteroid Therapy **37**

**Chapter 3 39**

Anti-TNF Therapy **61**

**Chapter 4 63**

**Chapter 5 87**

**Chapter 6 103**

Traditional Drugs: Mechanisms of Immunosuppressor and Corticosteroid

*by Cristina Ribeiro de Barros Cardoso, Amanda de Castro Habka, Camila Figueiredo Pinzan, Camilla Narjara Simão Oliveira,* 

Inhibitors of Tumoral Necrosis Factor Alpha in Inflammatory

Biological Therapy in the Prevention of Complications of Crohn

to Initiating and How to Proceed When Surgery Is Necessary

Biological Therapy for Inflammatory Bowel Diseases: Screening Prior

*by Maria de Lourdes Setsuko Ayrizono, Priscilla de Sene Portel Oliveira* 

*by Carlos Walter Sobrado, Natália Sousa Freitas Queiroz* 

Mucosal Immunology in the Inflammatory Bowel Diseases

The Role of TNF in the Pathogenesis of Inflammatory Bowel Disease

### Contents



Preface

The treatment of inflammatory bowel disease (IBD) has posed a major challenge since its appearance. Biomedical researchers, physicians, gastroenterologists, and surgeons have struggled to improve the quality of life of their patients and have sought, above all else, to keep the disease under remission for as long as possible. Blockers for tumoral necrosis factor alpha (TNF-α) were the first biological drugs to be discovered and for this reason they played a crucial role in the subsequent evolution of IBD treatment. The aim of this book is to provide an overview of such drugs and the latest developments in IBD immunopathology. Our contributors discuss the main indications, efficacy, and possible side effects of the different types of drugs

The book is divided into four parts. Section 1 deals with the immunopathological aspects of IBD with a special focus, in the second chapter, on the pathogenic role of TNF-α. Section 2 contains a single chapter with a critical assessment of corticoids and immunosuppressants, which preceded biological therapy. Section 3 discusses anti-TNF-α therapy in its general aspects of indication and action mechanisms. More specifically, it also deals with practical aspects concerning measures that should be taken before initiating biological therapy and indications for surgery. Lastly, Section 4 examines new types of biological therapy that have come after anti-TNF-α and that are now available in most countries around the world.

We hope that the reader will find this book to be a practical and concise resource on the clinical treatment of IBD that is also helpful in daily clinical practice. I would like to thank Prof. Dr. Tristan Torriani, co-editor of this book, for his assistance in the linguistic revision of the chapters, and also to Ms. Katarina Pausic

Associate Professor of Surgery Department, Colorectal Surgery Unit,

Coordinator of the IBD Research Laboratory,

Assistant Professor, School of Applied Sciences,

**Raquel Franco Leal**

**Tristan Torriani** Professor,

Limeira Campus, University of Campinas,

School of Medical Sciences, University of Campinas,

Professor,

Brazil

Brazil

for her attentive work throughout the planning and editing process.

available today for IBD treatment.
