**3.5 Multinodular goiter**

David Marine and Selwyn Taylor proposed that chronic intermittent stimulus leads to variable thyroid hyperplasia resulting in multinodular goiter [10]. Various factors including genetic heterogeneity of follicular cells, secondary elevation of TSH due to iodine deficiency, goitrogens, and inborn error of thyroid hormone synthesis are considered to be factors involved in pathogenesis of condition.
