Basic Sciences and Clinical Approaches

**Chapter 1**

Healing

**Abstract**

*Juin-Hong Cherng*

highly desirable properties.

**1. Introduction**

**3**

alginate polysaccharide, inflammatory response

due to poor availability of healthy tissue [3–5].

Calcium Alginate Polysaccharide

Patients with burn injuries suffer from pain and an inflammatory response; however, treatment methods are still not satisfactory and remain challenging. Due to the long stage of burn wound rehabilitation, which contributes to the long-term sensory problems, an effective treatment must begin at the outset of burn wound care. The functionalized wound dressing is expected to be a great treatment strategy over the commercialization wound dressing products and engineered skin substitutes nowadays. Some studies revealed the use of calcium alginate polysaccharide (CAPS) as an "active" dressing due to its calcium richness for wound healing and scar tissue formation. The outstanding outcome of CAPS dressing for severe burn injuries was indicated by natural wound healing and less scarring formation, minimum bacterial infection, cytokine enhancement regulation, and appropriate inflammatory response and pain regulation. These advantages affirmed the phytopolysaccharide dressing as the next generation of wound dressing materials with

**Keywords:** severe burn injuries, wound dressing, wound management, calcium

Burns are the most traumatic injuries and physically harmful because of long hospitalization and rehabilitation, which lead to significant morbidity and mortality [1, 2]. The development of effective treatment associated with burn injury is a major unmet medical problem. Current burn wound treatment methods, such as eschar excision, split-thickness skin autograft, and cell-based skin constructs, are still not satisfactory and remain challenging. Not only causing painful and relative costly treatment, but those methods are also very difficult to perform in patients

Despite any advances in burn management, how to treat wound properly at the outset of burn injury is the important key of an effective treatment. Most patients with burn injuries suffer from long-term pain and posttraumatic situation; therefore, an appropriate burn wound handling with a good dressing initially is expected to be a great way to minimize scar formation and accelerate burn wound healing.

Dressing as an Accelerated

Treatment for Burn Wound

### **Chapter 1**
