**4.5 Can newer generation DES bridge the gap?**

A total of 69 randomized trials that enrolled 24,015 diabetic patients with a total of 71,595 patient-years of follow-up satisfied our inclusion criteria. When compared with CABG (RR = 1.0), PCI with paclitaxel-eluting stent (RR = 1.57 [1.15–2.19]) or sirolimus-eluting stent (RR = 1.43 [1.06–1.97]) was associated with an increase in mortality. However, PCI with EES (RR = 1.11 [0.67–1.84]) was not associated with a statistically significant increase in mortality. In PCI with EES (RR = 1.31 [0.74–2.29]), the excess repeat revascularization was not statistically significant although the point estimate favored CABG. CABG was associated with numerically higher stroke. In patients with DM, evidence from indirect comparison shows similar mortality between CABG and PCI using EES. CABG was associated with numerically excess stroke and PCI with EES with numerically increased repeat revascularization [67].
