**5. Conclusion**


**57**

*Antiplatelet Therapy after Coronary Artery Bypass Graft Surgery, Inconsistency of Clinical…*

• Resistance to antiplatelet drugs and its impact to the clinical outcomes (bypass patency, major adverse cardiovascular events such as MI, PCI, re-do CABG, and cardiac mortality) of patients requires further investigation with larger

• It is reasonable to assume (and meta-analyses of studies consisting of patients with cardiovascular disease suggest) that patients who are resistant to ASA have a greater risk of clinically important cardiovascular morbidity long term

• Further studies are needed in order to define the role of more aggressive antiplatelet therapy post CABG on graft patency and clinical outcome.

• Besides optimal antiplatelet therapy, other variables such as surgeon experience and skill, stage and severity of CAD, long-lasting postoperative control of cardiovascular risk factors, the degree of reduction of systolic function of left ventricle before CABG, and other associated comorbidity (e.g., diabetes, chronic renal failure, etc.) have to be taken into consideration when interpret-

\*, Nenad Lakusic1,2,3, Krunoslav Fuckar1,2, Dusko Cerovec1,2

1 Special Hospital for Medical Rehabilitation Krapinske Toplice, Krapinske Toplice,

2 Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek,

3 Faculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University

© 2019 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium,

*DOI: http://dx.doi.org/10.5772/intechopen.90446*

than ASA-sensitive patients.

ing MACCE and CABG patient outcomes.

4 University Hospital Centre Zagreb, Zagreb, Croatia

provided the original work is properly cited.

\*Address all correspondence to: ivana.sopek92@gmail.com

5 Faculty of Medicine Zagreb, University of Zagreb, Zagreb, Croatia

studies.

**Author details**

Croatia

Croatia

Ivana Sopek Merkas1

and Kristina Maric Besic4,5

of Osijek, Osijek, Croatia

*Antiplatelet Therapy after Coronary Artery Bypass Graft Surgery, Inconsistency of Clinical… DOI: http://dx.doi.org/10.5772/intechopen.90446*

