**4. Peptide-based vaccine for nanotechnological prototypes**

Synthetic peptides alone are not sufficient to develop vaccine prototypes because they cannot stimulate the cellular and humoral protection system sufficiently. So, different adjuvant systems are formed by conjugating the peptides biopolymers or loading them into NPs, resulting in a high immune response [30]. The use of peptide-polymer complexes and peptide loaded nanoparticles are the best way for the developing the peptide-based vaccine prototypes.
