**Author details**

Muhammad Asraf Mansor and Mohd Ridzuan Ahmad\* Micro-Nano System Engineering Research Group, Faculty of Engineering, Division of Control and Mechatronic Engineering, School of Electrical Engineering, Universiti Teknologi Malaysia, Skudai, Johor, Malaysia

\*Address all correspondence to: mdridzuan@utm.my

© 2020 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

**111**

*Microfluidic Device for Single Cell Impedance Characterization*

electrical discrimination of cells at normal, apoptotic and necrotic status with a microfluidic device. Journal of Chromatography. A. 2011;**1218**(33):5725-5729

[10] Du E, Ha S, Diez-Silva M, Dao M, Suresh S, Chandrakasan AP. Electric impedance microflow cytometry for characterization of cell disease states. Lab on a Chip. 2013;**13**(19):3903-3909

[11] Liu Y-S, Banada PP, Bhattacharya S,

measurements. Applied Physics Letters.

Nemat-Gorgani M, Pease F, Ronaghi M, Davis RW. Targeted cell detection based on microchannel gating. Biomicrofluidics. 2007;**1**(4):1-10

[13] Gawad S, Schild L, Renaud PH.

spectroscopy flow cytometer for cell analysis and particle sizing. Lab on a

[14] Esfandyarpour R, Javanmard M, Koochak Z, Harris JS, Davis RW. Nanoelectronic impedance detection of target cells. Biotechnology and Bioengineering. 2014;**111**(6):1161-1169

Mulchandani A, Chen W. Capillary electrophoresis microchips for separation and detection of organophosphate nerve agents. Analytical Chemistry.

[16] Park K, Suk H-J, Akin D, Bashir R.

Micromachined impedance

Chip. 2001;**1**(1):76-82

[15] Wang J, Chatrathi MP,

2001;**73**(8):1804-1808

Dielectrophoresis-based cell manipulation using electrodes on a reusable printed circuit board. Lab on a

Chip. 2009;**9**(15):2224-2229

[17] Emaminejad S, Javanmard M, Dutton RW, Davis RW. Microfluidic

Bhunia AK, Bashir R. Electrical characterization of DNA molecules in solution using impedance

[12] Javanmard M, Talasaz AH,

2008;**92**(14):143902

*DOI: http://dx.doi.org/10.5772/intechopen.90657*

[1] Kantara C et al. Methods for detecting circulating cancer stem cells (CCSCs) as a novel approach for diagnosis of colon cancer relapse/ metastasis. Laboratory Investigation.

[2] Ciceron L, Jaureguiberry G, Gay F, Danis M. Development of a plasmodium

[3] Gilchrist KH et al. General purpose, field-portable cell-based biosensor platform. Biosensors & Bioelectronics.

PCR for monitoring efficacy of antimalarial treatment. Journal of Clinical Microbiology. 1999;**37**(1):35-38

[4] Jao J-Y, Liu C-F, Chen M-K, Chuang Y-C, Jang L-S. Electrical characterization of single cell in microfluidic device. Microelectronics and Reliability. 2011;**51**(4):781-789

[5] Yang L, Arias LR, Lane TS, Yancey MD, Mamouni J. Real-time electrical impedance-based

[6] Sun T, Morgan H. Single-cell microfluidic impedance cytometry: A review. Microfluidics and Nanofluidics.

Conference. 1956;**12**:1034-1040

[8] Holmes D, Morgan H. Single cell impedance cytometry for identification and counting of CD4 T-cells in human blood using impedance labels. Analytical Chemistry.

[9] Gou H-L, Zhang X-B, Bao N, Xu J-J, Xia X-H, Chen H-Y. Label-free

2010;**82**(4):1455-1461

[7] Coulter WH. High speed automatic blood cell counter and cell analyzer. Proceedings of the National Electronic

2011;**399**(5):1823-1833

2010;**8**(4):423-443

measurement to distinguish oral cancer cells and non-cancer oral epithelial cells. Analytical and Bioanalytical Chemistry.

2015;**95**(1):100-112

**References**

2001;**16**(7-8):557-564

*Microfluidic Device for Single Cell Impedance Characterization DOI: http://dx.doi.org/10.5772/intechopen.90657*
