*4.2.1.1 Differential scanning calorimetry (DSC)*

DSC is mainly employed to ensure drug incorporation into the s-SEDDS as well as the absence of drug-solid carrier interaction. It is also used to investigate the physical state (i.e., crystalline or amorphous) of the incorporated drug in the final formulation [94]. Transition from the crystalline to amorphous state is common in SEDDS formulations which lowers the drug melting point and improves its solubility and dissolution rate [95].
