Meet the editor

Jonathan S. Harrison obtained undergraduate and graduate degrees at the University of Chicago, prior to receiving his medical degree from the University of Illinois. Much of his career was spent in the medical education system of the State of New Jersey, which is now part of Rutgers University. He was subsequently the Nellie B. Smith Professor of Oncology and director of the division of Hematology and Oncology, University of

Missouri. Currently, he is a member of the Hemato-Oncology Institute at the Sheba Medical Center.

Contents

An Historical Overview of the Amyloidoses

*by Richa Juneja, Prasad Dange and Rahul Arora*

*and Paulo Renato de Oliveira*

*by Ivetta Danylesko*

*Dominik Waldmeier and Nisha Arenja*

**Preface XI**

**Chapter 1 1**

**Chapter 2 19**

**Chapter 3 37**

**Chapter 4 57**

**Chapter 5 73**

**Chapter 6 87** Non-Alzheimers Amyloidoses of the Neurological System: Cerebral Amyloid

*by Jonathan S. Harrison, Yossi Cohen, Irina Ioffe and Shlomo Bulvik*

Therapeutic Approaches for Alzheimer's Disease: New Perspectives *by Ivo Ilvan Kerppers, Andressa Panegalli Hosni, Andressa Leticia Miri,* 

*Mariane Maria Silveira Vieira de Lima, Ana Carolina Dorigoni Bini,* 

Diagnosis of Cardiac Amyloidosis Using Non-Invasive Technics *by Eva Strickler, Ernest Tsiaze, Gerrit Hellige, Dominik Zumstein,* 

A Short Review of Hematopoietic Transplantation for AL Amyloidosis

Diagnosis of Amyloidosis: From History to Current Tools

*Maria Elvira Ribeiro Cordeiro, Flávio Klinpovous Kerppers,* 

*Felipe Figueiredo Moreira, Patricia Pacheco Tyski Suckow, Eliane Gonçalves de Jesus Fonseca, Larissa Sakis Bernardi* 

Angiopathy and Familial Amyloid Polyneuropathy *by Gilad A. Muth, Jonathan S. Harrison and Rohan Arora*

## Contents


Preface

Amyloidosis occurs in a variety of clinical settings and can manifest in a wide spectrum of clinical presentations. It may occur as an inherited disease or it may be acquired during the lifetime of the affected individual due to a variety of underlying disease states. As a consequence of heterogenous etiologies and of the protean clinical presentations, it is often overlooked until irreversible end-organ damage has occurred. This volume provides an overview of some of the major topics in the very broad field of amyloidosis to aid in the understanding of the

The first chapter provides a historical overview of the key developments in the understanding of amyloidosis with respect to biology and diagnosis as well milestones in the treatment of the major subtypes of the disease. Subsequent chapters focus on a variety of subtypes of amyloidosis and provide more detailed discussions of the pathogenesis of specific forms of amyloidosis as well as examine treatment options for these subtypes. The final chapter discusses major hypotheses regarding the role of amyloid in Alzheimer's disease, a disorder that is a major healthcare issue worldwide but for which the details of its pathobiology remain to

be fully elucidated and for which treatment is entirely unsatisfactory.

There are medical journals devoted largely or entirely to amyloidosis and

therefore one may ask what the role of yet another volume on the topic might be. New insights are being gleaned into the varied subtypes of amyloidosis yearly, and current updates are of value in stimulating thought and moving the basic and clinical investigation forward. More fundamentally, if even one patient ultimately benefits from the works contained herein, then this present volume may be judged

This book is dedicated to George P. Studzinski, MD, Ph.D., Professor Emeritus, Rutgers University, a meticulous scientist, an accomplished educator, and an

> **Jonathan S. Harrison** Hemato-Oncology Institute,

> > Ramat Gan, Israel

Sheba Medical Center – Tel HaShomer Hospital,

nature of amyloidoses.

a success.

exemplary mentor.
