**Abstract**

The Duffy group system includes six known antigens that reside on a glycoprotein which acts as a receptor for chemokines. It is also a receptor for some malaria species. There are significant racial variations in expression of Duffy antigens. Approximately 68% of Blacks lack both Fya and Fyb antigens. Individuals with this unique phenotype are resistant to two malaria species. Antibodies formed against the Duffy antigens are of IgG subclass and are clinically significant as they can be implicated in acute and delayed hemolytic transfusion reactions as well as hemolytic disease of fetus and newborn. Patients who form anti-Fya or anti-Fyb must receive antigen negative blood units in the future.

**Keywords:** Duffy, RBC antigens, FYA, FYB, DARC, hemolysis, fetus, HDFN
