**5. Conclusions**

There is paucity of data on the distribution of clinically significant blood group antigens apart from ABO and Rhesus D among Nigerians. Management of Rhesus D negative pregnancies and pregnancies associated with clinically significant alloantibody is suboptimal. This failure in stewardship by the Nigerian government has a significant implication for Haemolytic Disease of the Foetus and Newborn and haemolytic transfusion reaction. There is need to introduce routine screening of pregnant women in Nigeria for clinically significant red cell antibodies to facilitate the effective management of HDFN as well as prevent HTR by enabling the selection of antigen negative red cells for women who have alloantibodies and require a red cell transfusion.
