**1. Introduction**

Malaria is one of the deadliest diseases to affect humans, with the latest WHO reports indicating ~445,000 deaths in 2017 alone [1]. More alarmingly, despite decades of advances in controlling the malaria epidemic, death rates caused by malaria seem to have plateaued in the past 3 years, indicating drug resistance and re-emergence. Drug resistance to the current frontline antimalarials have been confirmed by many recent studies and steadily observed over increasing geographic coverage [2]. Thus, it is of utmost importance to develop novel antimalarials, with different modes of action and distinct targets, if possible in conjunction, to check the onslaught of malaria. This chapter looks at such potential scope for antimalarial drug development: disruption of protein-protein interactions in the malaria parasite *Plasmodium*, crucial for survival and proliferation.
