**1.6 Production of glycoproteins**

*Some RNA Viruses*

**Figure 2.**

sGP, GP1, GP2, and ssGP [41, 42].

*Important proteins in the RNA genome of EBOV [43].*

the major and minor matrix protein VP40, VP24, respectively. Then, the matrix proteins are encapsulated by a double layer of lipid which is then peppered with the viral glycoprotein (GP) that help in binding to the host cell [39, 40]. All five EBOV species discovered so far has the same GP gene organization which is divided into

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**Figure 3.**

**1.5 Structure of glycoproteins**

*The virion structure showing the nuclear material and glycoproteins [44].*

It has been observed that most of the viral components play an active role in the pathogenesis and infection of this viral disease, but the major role is played by the glycoproteins of the EBOV [45]. Thus, they possess a significant importance in the virulence of EBOV and targeting its synthesis is one of important step for controlling this infection [45]. EBOV includes different glycoproteins each of which plays their roles in different aspects of viral life cycle. Each gene product

The biosynthesis of glycoproteins occurs by transcription and expression strategies. The precursor of the secreted glycoproteins and full length glycoproteins are the initial products of EBOV glycoprotein. Pre-sGP is transcripted and translated to soluble products sGP and ∆-peptide while glycoprotein GP1, 2 is cleaved to GP1 and GP2. These two fragments are linked together by disulfide-bonding (S▬S). The GP1 helps in binding to the host cell and has a crucial role of EBOV entry across the host cell membrane [49]. The flowchart is shown in **Figure 4** [45].
