Ebola, the Negative Stranded RNA Virus

*Aqsa Farman, Syed Lal Badshah, Khalid Khan, Nasir Ahmad and Abdul Naeem*

### **Abstract**

Ebola virus (EBV) is a deadly virus that has resulted in a number of deaths during its outbreaks in Africa in 2014–2016 and 2018–2019. This virus causes a hemorrhagic fever like other pathogenic viruses of the Filoviridae family with high mortality rate. The exact reservoir of the ebola virus is not known, but different mammal groups are the source from which it is transferred to the human population. The transmission among the human population is through body fluids of patients and also through aersol droplets in the air. The role of different glycoproteins in the budding formation has helped a lot in understanding the physiology of the ebola virus. Most of these viral glycoproteins synthesis and the replication enzymes offer a good inhibitory target for drug design against the ebola virus. Recently, different groups have claimed the development of a successful vaccine for the ebola virus. However, the availability of the vaccines to the poor population of Africa and other parts of the world is still not practical.

**Keywords:** Ebola virus, hemorrhagic fever, vaccine, glycoproteins, molecular docking
