**7. Final marks**

These lessons derived of SARS-CoVs infections outbreaks (2003 and 2019) can explain the role of the two antagonistic RASs pathways on the hypoxic pulmonary vasoconstriction an homeostatic mechanism in response to alveolar hypoxia secondary to acute lung injury in SARS, optimizing ventilation, perfusion and systemic oxygen delivery. Moreover, the new knowledge about the role of RAS proteins, namely, ACE-2 in gut with pleiotropic actions on the metabolism of tryptophan in the crosstalk microbiota–intestine, intestine-kidney and probably intestine-lung can help in designing new, based on probiotics and prebiotics or repurposing ancient therapies for disorders involving those organ crosstalk resultant physio pathologies.

### **Acknowledgements**

The authors would like to acknowledge the Instituto de Investigação Científica Bento da Rocha Cabral and Sociedade Portuguesa de Papillomavírus for support.

**47**

*Renin Angiotensin System, Gut-Lung Cross Talk and Microbiota. Lessons from SARS-CoV…*

Andreia Matos1,2,3,4\*, Alda Pereira da Silva5,6, Joana Ferreira1,2, Ana Carolina Santos1,2, Maria Clara Bicho7,8 and Manuel Bicho1,2

1 Genetics Laboratory and ISAMB - Environmental Health Institute - Ecogenetics and Human Health Unit, Faculty of Medicine of University of Lisbon, Av. Prof. Egas

2 Instituto de Investigação Científica Bento da Rocha Cabral, Lisbon, Calçada Bento

3 Tumor and Microenvironment Interactions Group, i3S - Instituto de Investigação e Inovação em Saúde/INEB-Institute of Biomedical Engineering, University of

4 Abel Salazar Institute for the Biomedical Sciences (ICBAS), University of Porto,

5 ISAMB - Environmental Health Institute - Ecogenetics and Human Health Unit, University Clinic of General and Family Medicine, Institute for Preventive Medicine and Public Health, Faculty of Medicine, University of Lisbon, Av. Professor Egas

6 CBIOS - Biosciences Research Center, School of Health Sciences and Technologies,

Universidade Lusófona, Campo Grande 376,1649-024, Lisboa, Portugal

Medicine; Av. Prof. Egas Moniz, Piso 1C, 1649-028, Lisboa, Portugal

\*Address all correspondence to: andreiamatos@medicina.ulisboa.pt

7 Institute of Preventive Medicine and Public Health and Genetics Laboratory and ISAMB - Environmental Health Institute of University of Lisbon Faculty of

8 Dermatology Research Unit, Instituto de Medicina Molecular, Av. Prof. Egas

© 2020 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium,

*DOI: http://dx.doi.org/10.5772/intechopen.94325*

Moniz, Piso 1C, 1649-028 Lisboa, Portugal

da Rocha Cabral, n°14, 1250-047, Portugal

Moniz, Piso 1C 1649-028, Lisboa, Portugal

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**Author details**
