**8. Regulatory perspective of nanobiotechnology**

In the event that we talk about the most recent decade, nano bio-innovation has generated some new impedance for the research community, industry, and regulators. Applicable techniques have some loopholes regarding fabrication and processing of nano medicines, that's why special provisions would be required to tide-over such complications [32]. FDA and other regulatory authorities experience many unavoidable consequences for the release of such products. This is due to non-authentic validation program in clinical trial phase [11]. A wing of researchers proposes sturdy contentions, revealing both positive and negative aspects pertaining to the advancement of nano-materials. They suggest that vague protocol throttle research and product development, which represses the development and viability of new nano-medicines. Apart from that, a robust administrative body is made so as to push the business advancement by creating certainty for pharmaceutical firms and trust within the ultimate consumers [33]. Currently, the FDA, EMA (European medical agency), and other regulatory agencies examine each new nanoparticle individually. There is commonly an absence of benchmarks in the assessment of nano-medicines as a unique class of therapeutic agent [34]. Afterwards, administrative corporations might imagine of a complete listing of screening and a powerful approbate system that enclose the complete variety of particle characterization, pharmacology, and toxicology troubles.

## **9. Future prospects**

In case we consider in trendy approximately the two major capabilities of nanobiotechnology, first is imaging and diagnostics (quantum dots) and second are proteomics. In proteomics especially study and detect about nucleic acids and proteins [35]. Currently, the Thermal Sensitive drug delivery system has been developed for the treatment of cancer. In this, drug is given in the injection form, which reaches inside the body and converts into insoluble form and accumulates in the tumor cells because the temperature of the tumor cell is more than the normal cell [36]. In spite of the tremendous credibility of nanobiotechology, its use has been considerable due to its toxicity and environmental problems. Despite all this, the drug delivery, drug discovery, gene therapy, molecular imaging, biomarkers, and biosensors fields are exploring possibilities in the nanobiotechnology. Nanobiotechnology has brought a bright future for the clinical diagnosis and targeted drug delivery sector. Now in the field of diagnosis, it has become easier to detect diseased cells rapidly, due to which it is possible to prevent diseased cells from spreading in the body [37]. There is a constant development in this field right now and it is possible that some incurable diseases in the future will actually be cured with the resources of nanobiotechnology.
