*2.1.1.8 Enteritidis fimbrial SEF14*

Enteritidis fimbrial SEF14 contributes to colonization of chicken intestine, liver, spleen and reproductive organs [46, 47]. The fragment encoding genes responsible for SEF14 biosynthesis contain three genes, *sefABC*. The putative adhesion subunit encoded by *sefD* is essential for efficient uptake or survival of Enteritidis in macrophages, as the *sefD* mutants were not readily internalized by peritoneal macrophages compared with the wild-type bacteria soon after intraperitoneal infection of mice [48]. The *sefD* mutant was severely attenuated after both oral and intraperitoneal infection of BALB/c mice (approximate LD50: >104 (mutant) vs. <10 (wild type)) [48]. In the mouse model, egg-yolk derived anti-SEF14 antibodies afforded passive protection [49].
