*2.3.7 Nitric oxide generators*

Exogenous generation of nitric oxide (NO) by agents, for example, sodium nitroprusside has been shown to trigger the bacterial growth from the biofilm form to the planktonic form via the reduction of the level of cyclic di-GMP inside the bacterial cells [104]. Further NO-generators, for example, S-nitroso-N-acetyl penicillamine and S-nitroso-l-glutathione were found also to induce the dispersion of *P. aeruginosa* biofilm [124]. The dispersion of biofilm by NO-generators was also demonstrated in *B. subtilis* [125]. Recently, it has been reported that catheters charged with NO prevented the adherence and the colonization of *P. aeruginosa*, *E. coli* and *C. albicans* on their surfaces [126].
