*2.1.2 Non-fimbrial adhesins*

Four distinct non-fimbrial intestinal colonization factors have been identified:

#### *2.1.2.1 MisL*

MisL encoded within the SPI-3, is an outer membrane fibronectin-binding autotransporter protein which is induced upon bacterial contact with the intestinal epithelial cells, and is required for colonization of the murine cecum and for intestinal persistence. MisL binds fibronectin and collagen IV via its passenger domain [50].
