**2.4 Systemic infection/dissemination**

Internalization of the infecting *Salmonella* within SCV is followed by systemic spread through other target organs, such as the spleen and liver. As a prerequisite for spread, the bacterial cells must evade the innate immune system. During this process, serum resistance or resistance to complement-mediated serum killing is a major virulence factor for the development of systemic salmonellosis. It involves three major factors, namely LPS, outer membrane proteins PagC and Rck and siderophores (**Table 4** and **Figure 1**).
