**3. Conclusion**

Various approaches have been developed for competing microbial virulence and resistance. Quorum sensing signals and global regulators play an essential role in controlling the gene expression of virulence factors, and the expression of proteins required for adaptation to environmental and stress condition. Therefore, control of these regulators will stop the microbial pathogenicity. In addition, biofilms act as a defense mechanism against host immunity and antimicrobial therapy. Natural and synthetic compounds have approved activities in eradication of biofilm formation. Besides, phage therapy, which is currently successful in destruction of bacterial pathogens that do not respond to conventional antimicrobials. These methods would open up new perspectives for management the up growing problem of microbial resistance. Further, *in vivo* studies are required for real applications of these trends in eradication of microbial infections.
