**5.3 Acyclovir, valacyclovir and other antiretroviral drugs**

Oral antivirals are not a regular treatment modality, but isolated case report about improvement in wart lesion after oral treatment with acyclovir [112], valacyclovir are there. Plantar wart is cleared completely with 1 gm valacyclovir for 60 days [113]. Improvements of wart with intravenous cidofovir in one HIV seropositive patient with complete clearance are available [114]. Nearly total clearance of multiple viral wart with didanosine, stavudine and efavirenz triple antiretroviral therapy in a 34-year-old male homosexual patient was seen, accompanied by a significant improvement in immune status [115]. The observations are not powerful enough to assume causality (instead of a simple casual or placebo effect).
