**7. Immunotherapy**

This treatment uses the patient's own immune system to fight the warts. Some types of immunotherapy only target certain cells of the immune system. Others affect the immune system in general. Because of the cumbersome nature of the conventional procedures and a high risk of recurrence, immunotherapy is becoming more and more popular, especially in the treatment of refractory cutaneous and genital warts. These include various topical, intralesional and systemic agents. There are no well-defined criteria or consensus on when immunotherapy should be tried in a patient with warts. Current indications [134] include the following (**Table 1**).


4.Difficult-to-treat areas—periungual and palmoplantar sites
