**1. Introduction**

Human papillomaviruses (HPVs) are a large and diverse group of viruses with 174 completely characterised types, with new HPV types being continuously found [1]. There are five major HPV genera: *Alphapapillomavirus*, *Betapapillomavirus*, Gamma papillomavirus, Mu papillomavirus and Nu papillomavirus. HPVs infect epithelial cells in genital mucosa (*Alphapapillomaviruses* only), oral mucosa or skin (representatives of all five genera). The most common clinical manifestation is verruca, with different morphological forms. The histology shows acanthosis, elongation of dermal papillae, presence of vacuolated cells and koilocytes. Subclinical manifestations are invisible to the human eye. These subclinical lesions are flat and multiple. Their clinical insignificance facilitates their spread, and in women their persistence is possibly related to genital cancer.
