*4.8.1 Mixture of dimethyl ether and propane (DMEP)*

It is in aerosol form, easy to handle and stored in normal room temperature, and its preservation time is very high (nearly 3 years), available in market and easy to buy. As the evaporation temperature reaches −57°, therefore, it is likely to be less effective, and efficacy in inducing tissue temperatures adequate for cell necrosis appears low [26]. But one multicentre RCT on comparing effects of DMEP and LN2 shows that no clinically relevant differences between the efficacy, tolerance and safety of the two cryogenic agents used in primary care were found. The low freezing of DMEP was sufficient for the cryotherapy of benign lesions [27].
