**Abstract**

Aquaculture continues to be the fastest-growing food production field that has a lot of potential to meet the aqua-protein needs. The scientific and business communities are responding to the many challenges and opportunities inherent in the growing aquaculture field. Advancements in production and detection of harmful material systems and technologies are contributing to aquaculture industry's expansion and sustainability. All of these production system technologies are benefitting from expanding information and communication systems, which are enabling advances in every stage of production. In the future, the new farming operation of friendly environment will focus on the use of nonecology destructive substances, no antibiotics, and the natural probiotics or novel immunomodulatory substances to match the physiological regulation of cultured organisms and the management of aquaculture. The future scientific-based innovation will contribute toward meeting increasing food demands, while improving social, environmental, and financial sustainability of the global aquaculture industry.

**Keywords:** aquaculture, immunomodulatory, prevention management, probiotics, surface-enhanced Raman scattering

### **1. Introduction**

As the catch of marine fisheries is decreasing year by year, the demand for aquaculture products in human food supply sources is increasing year by year. However, the rapid spread of aquatic diseases, reduced area of farmed land, or the decreased need of environmental conservation caused the deterioration of the global cultivation of aquatic animal environment. Now, the emphasis on ecological environmental protection and the risk of biological threats after the use of aquatic animal drugs are gradually proven and discovered.

In the future, the new farming operation of friendly environment will focus on the use of nonecology destructive substances, no antibiotics, and the natural probiotics or novel immunomodulatory substances to match the physiological regulation of cultured organisms [1] and the management of aquaculture [2–4], resulting in a good immune disease strategy for breeding organisms. Furthermore, rapid disease screening technology reduces the risk of disease spread that is prone to occur in manual operations.
