**Acknowledgements**

This work was supported by Fondecyt Grant 1150759 (PC), Proyecto de Mejoramiento Institucional postdoctoral fellowship PMI-UDD from Instituto de Ciencias e Innovación en Medicina (ICIM-UDD). Postdoctoral fellowships by Fondecyt and project ICM-MINECOM, RC-130006-CILIS, granted by Fondo de Innovación para la Competitividad del Ministerio de Economia, Fomento y Turismo, all of them from Chile.
