*2.5.2 Trilateral RB*

Trilateral retinoblastoma indicates the concomitant presence of a heritable retinoblastoma and a midline tumor or a pineoblastoma [12, 69]. Around 5–13% of patients with RB develop trilateral retinoblastoma [70]. Therefore, in children with heritable retinoblastoma, a brain magnetic resonance imaging with gadolinium contrast every 6 months is recommended until the age of 5 years [71].
