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## Meet the editors

Luis Tejedor is a general surgeon with a particular interest in surgical oncology. His concerns led him to set up a complete and authoritative multidisciplinary Committee of Tumors in his hospital more than 25 years ago and to become a fellow of the European Board of Surgery Qualification in Surgical Oncology since its first announcement in 2003. In his clinical practice he has focused mainly on breast cancer, expanding his skills with

masters, courses and attendances to breast cancer leading hospitals. He has been performing oncoplastic and reconstructive breast surgery for more than 20 years in the Breast Unit of his National Health System Hospital.

Susana Gómez Modet is a medical doctor who graduated from the University of Cádiz Medicine School, Spain, in 2000. She was trained as a General Surgeon in Málaga, Virgen de la Victoria Hospital from 2002 to 2007. Since then she has worked as a general surgeon, mainly in the Oncology Breast Surgery at Punta Europa Hospital, Algeciras, Cádiz, Spain. She completed her training in Senology with other academic titles: a Masters in

Breast Diseases and Senology from the Barcelona University and an Expert Course in Oncoplastic and Reconstructive Surgery of the Breast. She is currently part of the Breast Unit and of the Committee of Breast Cancer in Punta Europa Hospital.

Associate Professor Lachezar Ivanov Manchev (MD, PhD) graduated in medicine from the Medical Faculty, Trakia University, Stara Zagora in 2010. Since 2010, he has worked as a radiologist in the Department of Diagnostic Imaging at the University Hospital, Stara Zagora. Between 2013 and 2018, he was assistant professor in the Department of Radiology in the Medical Faculty, Trakia Universtity, Stara Zagora. Since 2018, he has been an

associate professor in Radiology at the same university. In his practice, he presents lectures and tutorials in Bulgarian to medical, nursing, midwifery and rehabilitation students, in subject areas including X-ray, CT, MRI, angiography, mammography, ultrasound and DSG. Dr Manchev also delivers lectures and tutorials in English to medical students from the United Kingdom and the Republic of Ireland. Since 2016, he works as a part-time lecturer for the Faculty of Public Health and Health Care, University Professor Doctor Asen Zlatarov, Burgas, Bulgaria.

Dr Arli Aditya Parikesit is the Head of the Bioinformatics Department at i3L. He finished his bachelor and master degrees, both in Chemistry, from the University of Indonesia. In order to pursue his degree in Bioinformatics, he accepted a DAAD (German Academic Exchange Service) fellowship to conduct his doctorate research with the Bioinformatics Group, Faculty of Informatics and Mathematics, University of Leipzig, Germany. His

doctoral research is focused on the utilization of modern protein domain annotation techniques to the three domains of life. In addition, Dr Arli is also an expert on immunoinformatics, in silico drug design, and in silico transcriptomics.

Contents

**Section 1**

Principles

**Section 2**

*and Elena Kotomina*

New Features Technique *by Anwar Yahy Ebrahim*

*by Naren Basu and D. Gareth Evans*

Cancer in Sardinian Population

**Preface XI**

Oncologic Issues **1**

**Chapter 1 3**

**Chapter 2 23**

**Chapter 3 33**

**Chapter 4 49**

**Chapter 5 65**

Breast Conservative Surgery: Oncoplasties **79**

**Chapter 6 81**

Electrical Impedance Mammography: Screening and Basic

*by Alexander Karpov, Marina Korotkova, Gregory Shiferson* 

Detection of Breast Cancer in Mammograms through a

Breast Cancer and *BRCA1* and *BRCA2* Pathogenic Variants

*by Grazia Palomba, Giuseppe Palmieri, Antonio Cossu,* 

*Panagiotis Paliogiannis and Maria Cristina Sini*

*by Ashley A. Woodfin and Anuja K. Antony*

Oncoplastic Surgery in Breast Cancer

Epidemiology and Genetic Susceptibility of Breast and Ovarian

Genetic Mutation Carriers: Special Considerations for Their Influence on a Modern Breast Reconstruction Practice

*by Atallah David, Moubarak Malak and Abdallah Abdallah*

### Contents



Preface

"the primary mission of a physician is to help his or her patients; the higher mission of a medical textbook is to help other physicians help even more patients". With this target in mind, this book has been devised to collect some recent data on a worldwide health problem. Breast cancer constitutes a notable problem in women's health and therefore a burdensome weight for society. Attempts to widen the knowledge on this disease, either at its preclinical (genetics) or clinical phase (diagnosis, treatment) are always welcome since they may lead to a decrease in the suffering (pain, physical dysfunctions, disfiguration, depression and so on) and a lengthening in survival of the patients. Authors have been busy to provide valuable information in these areas, so it is my hope that this book contributes in part to

> **Luis Tejedor MD, FACS, FEBS-SO** Chairman of General Surgery Service,

> > Hospital Punta de Europa,

**Dr. Susana Gómez Modet**

**Lachezar Manchev, PhD** Associate Professor, Trakia University, Stara Zagora, Bulgaria

**Dr.rer.nat Arli Aditya Parikesit** Department of Bioinformatics,

Indonesia International Institute for Life Sciences,

Algeciras, Spain

Cádiz University,

Jakarta, Indonesia

Spain

Quoting one of the great masters in breast reconstruction, Scott L Spear,

the mission expressed above.
