Meet the editors

David G. Churchill is a full professor in the Department of Chemistry at Korea Advanced Institute of Science and Technology (KAIST). He is an adjunct professor in the KAIST Institute for Health Sciences and serves as Head of the International Faculty Council at KAIST. His current research interests relate to main group synthetic chemistry and dementia research; his publications have recently focused on chemosensing and porphyrinoid

chemistry. He has created and (co)organized the biannual International Symposium of Molecular Neurodegenerative Disease Research (ISMNDR) at KAIST (Korea, Daejeon), which was initiated in 2012. He has given seminars worldwide, published more than 120 articles in peer-reviewed journals, and has an H-index of 31. In 2017, he served as an associate visiting professor at IIT Technion in Haifa, Israel.

Maja Dutour Sikirić received her doctorate from the Faculty of Sciences, University of Zagreb. During her studies she has acquired experience and developed an interest in organic - inorganic interactions in crystallization, as related to biomineralization, and physicochemical properties of novel gemini surfactants in solution and solid state. She joined Casali Institute of Applied Science, The Hebrew University of Jerusalem for Postdoctoral

studies during which she was working on the development of organic-inorganic nanocomposites, to be used as coatings for metal prosthetic implants. After returning to Ruđer Bošković Institute she has continued her work on crystallization of calcium phosphates, nanocomposite biomaterials as well as using DLS for characterization of nanoparticles in different matrices. She is currently employed as Head of the Laboratory for biocolloids and interface chemistry, Division of Physical Chemistry.

Helga Füredi-Milhofer received PhD from the Faculty of Sciences, University of Zagreb in 1963. Subsequently she was postdoctoral researcher at Case Institute of Technology Cleveland Ohio, USA. In 1956. she joined Ruđer Bošković Institute, where she was the head of Laboratory for Precipitation Processes from 1976 – 1995. In the period 1990-991 she was visiting professor at the Weizman Institute of Science, Rehovot, Israel and from

1991-1992 at Casali Institute of Applied Chemistry, the Hebrew University of Jerusalem, Israel. In 1995 she returned to Casali Institute of Applied Chemistry where she was professor until retirement. Her research interests are i) nucleation, growth and phase transformation of ionic and molecular crystals ii) biological and pathological mineralization iii) 0rganic-inorganic nanocomposites based on amorphous and crystalline calcium phosphates.

Božana Čolović graduated in 2007 and received her PhD degree in 2013, from the Faculty of Technology and Metallurgy, University of Belgrade. Since 2007 she has been employed at Vinča Institute for Nuclear Sciences. Her research is focused on development of biomaterials for application in bone tissue engineering and dentistry: synthesis of ceramics (hydroxyapatite, calcium silicate) and their modification with surface active substances

Contents

**Section 1**

**Section 2**

Disease and Health

Bone Mineralisation

*and Dean S. Rosenthal*

*by Paweł Kafarski*

*by Pinki Dey*

**Preface XI**

Introduction **1**

**Chapter 1 3**

Dynamics of Phosphates and Normal Biological Function **21**

**Chapter 2 23**

**Chapter 3 35**

**Chapter 4 53**

**Chapter 5 71**

**Chapter 6 95**

*by Marta Kalka, Anna Zoglowek, Andrzej Ożyhar and Piotr Dobryczycki*

Inorganic Polyphosphates Are Important for Cell Survival and Motility of Human Skin Keratinocytes and Play a Role in Wound Healing *by Cynthia M. Simbulan-Rosenthal, Bonnie C. Carney, Anirudh Gaur, Manish Moghe, Elliott Crooke, Lauren T. Moffatt, Jeffrey W. Shupp* 

Phosphonates: Their Natural Occurrence and Physiological Role

Introductory Chapter: Phosphorus - Nature's Versatile Pentavalent and Tetrahedral Covalent Building Block and Agent for Energy,

*by Woohyun Lee, Ariq Abdillah, Jaymee Palma and David G. Churchill*

Phosphorus: A Boon or Curse for the Environment?

Proteins in Calcium Phosphates Biomineralization

*by D. Sayantan and Sumona Sanyal Das*

to improve biocompatibility, as well as the deposition of bioactive coatingson the surface of metal implants to improve their mechanical and corrosion properties. So far, she has published 1 chapter in a book, 30 papers in international journals and 10 papers in national journals, presented 21 papers at international conferences and gave 3 invited lectures.

## Contents



Preface

Written by experts in the field, this book addresses a diverse set of topics regarding phosphorus chemistry, namely phosphates and closely related chemical systems. Both the natural and the synthetic aspects of phosphates and in some places phosphonates are presented in this book, which is divided into two parts: "Dynamics of Phosphates and Normal Biological Function" and "Phosphates in Biomaterials." The disciplines extend through biochemistry, chemistry, materials science, and engineering. We hope that this contribution serves as both a solid information source as well as a basis for inspiring future discoveries. We are grateful to all contributors and editors and wish them well in their careers and safe travel when conference-going.

**David G. Churchill**

**Maja Dutour Sikirić**

Zagreb, Croatia

Jerusalem, Israel

**Božana Čolović**

Belgrade, Serbia

Ruđer Bošković Institute,

**Helga Füredi-Milhofer**

Casali Institute of Applied Cheistry, The Hebrew University of Jerusalem,

Vinča Institute of Nuclear Sciences,

Molecular Logic Gate Laboratory, Department of Chemistry,

Daejeon, Republic of Korea

(Therapeutic Bioengineering), Daejeon, Republic of Korea

Korea Advanced Institute of Science and Technology (KAIST),

KAIST Institute for Health Science and Technology (KIHST)

Laboratory for Biocolloids and Surface Chemistry,

*by Latefa Sail*
