**3.3 Mechanisms of KLF4-mediated MDSC plasticity**

MDSC plasticity, and in general, myeloid plasticity, is regulated by the local microenvironment. These cells are environmental sensors and adapters [25]. In tumor, myeloid cells are the most abundant immune cells, and signals within the tumor microenvironment instruct these cells to change their dynamics and plasticity. There are many potential factors/mechanisms in these processes, including hypoxia, tumor ER stress, exosomes, and tumor-derived soluble factors [76]. In the following discussion, we will focus on KLF4-mediated plasticity of MDSCs in cancer and wound healing based on our recent studies.
