*2.3.4.1 Metabolism and health aspect*

The FDA tried to ban saccharin in 1977 because animal studies have revealed that it caused cancer in rat. But there is no supportive evidence to show the carcinogenic effect of saccharin at lower doses. Saccharin is now permitted to use in beverages, processed food and sugar substitutes and level of saccharin is to be indicated in the label [7]. Saccharin causes a headache, breathing difficulties, skin eruptions and diarrhea.
