**5. Gut microbiome changes**

Gut microbiome is diverse, varies between individuals, and can fluctuate over time. Western gut microbiome has less species than non-Western gut microbiome.

In addition to several pathological conditions that can alter gut microbiome composition, multiple factors are responsible for the changes in gut microbiome (**Figure 3**) [12, 15–31].

**Figure 3.** *Multiple factors can impact gut microbiome (Picture downloaded from the Internet).*
