*2.3.6.1 Metabolism and health aspects*

Neotame is rapidly metabolized by esterase present throughout the body into methyl ester and also forms a minor amount of methanol. This metabolic process yields de-esterified neotame which is completely eliminated from the body in urine and feces within 72 h. It is safer to use with people suffering from phenylketonuria because t-butyl group is added to the free amine group of aspartic acid breaks the peptide bond between the aspartic acid and phenylalanine, thus reduce the availability of phenylalanine which is responsible for phenylketonuria [9]. Neotame causes some of the toxic effects at high doses in the human such as it to reveal changes in body weight and food consumption and headache.
