Meet the editors

Hala Gali-Muhtasib is a tenured professor of cell and cancer biology at the American University of Beirut, Lebanon. She received her PhD from Kansas State University, Manhattan, USA. She is a prominent scholar with outstanding scientific contributions to the study of the role of natural products in cancer therapy, in addition identifying their cellular and molecular mechanisms of action. Her recent research interests include

identifying stem cell therapeutics and enhancing drug delivery by nanoparticle encapsulation of natural products. She has published more than 95 peer-reviewed articles, more than 10 book chapters, and has edited a few books. Gali-Muhtasib has received many research awards for her contributions to advancing the field of natural product drug discovery and drug delivery.

Omar Nasser Rahal is a physician scientist who earned his MD degree with outstanding performance from SABA University School of Medicine, Caribbean, Netherlands. He earned his Bachelor of Science degree in Biology from the American University of Beirut, Lebanon, and was further appointed as a translational cancer researcher in the field of molecular biology and anticancer drug discovery. His research interests are in the

field of oncology with a focus on translational research, systematic and comparative reviews, case studies, and clinical trials. Omar has co-authored six peer-reviewed articles and one book chapter. His passion for research along with his clinical career has contributed to the improvement of the quality of the healthcare system in the United States.

Contents

**Section 1**

Cell Death in Human Cancer

Myeloproliferative Neoplasms

*by Mehtap Kara and Ezgi Oztas*

*by Hai Zhang and Zhinan Chen*

*by Samo Ribarič and Irina Milisav Ribarič*

*and Coralia Bleotu*

**Section 2**

**Preface III**

Programmed Cell Death Mechanisms **1**

**Chapter 1 3** The Underlying Mechanisms of Chinese Herbal Medicine-Induced Apoptotic

**Chapter 2 25**

**Chapter 3 51**

**Chapter 4 65** Cell Death Mechanisms of the Promising Anticancer Compound Gallotannin

Autophagy and Cell Death **85**

**Chapter 5 87**

**Chapter 6 109**

Autophagy and Cell Death: Antitumor Drugs Targeting Autophagy

Autophagy and Cell Death in Alzheimer's, Parkinson's and Prion Diseases

*by Feiyu Chen, Zhangfeng Zhong, Hor Yue Tan, Ning Wang and Yibin Feng*

*Mihaela Chivu-Economescu, Laura G. Necula, Lilia Matei, Denisa Dragu,* 

Programmed Cell Death Deregulation in BCR-ABL1-Negative

*Saviana Nedeianu, Ana I. Neagu, Aurelia Tatic, Diana Cristodor* 

*by Carmen C. Diaconu, Petruta Gurban, Cristina Mambet,* 

Endoplasmic Reticulum Stress-Mediated Cell Death

*by Marwa Houssein and Hala Gali-Muhtasib*

## Contents


Preface

Programmed cell death is a normal and vital physiologic process, the aberrant regulation of which is a cancer hallmark and is a causative factor for many diseases. Knowledge of cell death mechanisms has expanded in the past years based on extensive research in the basic and clinical arena. This book compiles the latest research in the field and will be of interest to basic scientists, clinicians, and

**Hala Gali-Muhtasib**

**Omar Nasser Rahal**

Lebanon

Lebanon

Department of Biology and Department of Anatomy,

Cell Biology and Physiological Sciences,

American University of Beirut,

Beaumont Health Care System, Dearborn, Michigan, USA

Center for Drug Discovery, American University of Beirut,

graduate students.
