**4. Conclusions**

This analysis aims at the review of the latest advances of MLT modified-release oral solid dosage forms including the design of experiments approach. Many scientists have focused on the different ways in manufacturing modified-release oral solid formulations by using various excipients, dosage forms (multilayer or bilayer, coated or uncoated tablets), liposomes, alginate beads, nanofibre mats and nano−/ microparticles, or by employing a variety of techniques (i.e. dry coating, electrospinning, experimental design, etc.) in order to gain knowledge for the production of such dosage forms.

### **Conflict of interest**

The authors declare no conflict of interest.
