**Abstract**

The purpose of this study is to clarify the effects of the smelling "Zuko", incense rubbing into hands and putting the hands for the human brain. From our previous studies on the smelling an incense odor with putting the hands together, the activities of "Zuko" incense are also considered to be promoted as the imitation of habitual behaviors by mirror neurons and the default mode network in our brain. In this experiment, the brain activation was measured in 10 healthy adult volunteers who did or did not have a habit of putting their hands together and magnetoencephalography (MEG) data were recorded while the participants smelled "Zuko" incense and putting their hands together. The peak response of MEG P300m for the "auditory odd-ball paradigm" was also measured for a rare auditory pulse stimulation and was more enforced by the smelling "Zuko" incense. We used alpha-amylase value as an index of the stress state measured in the state before and after smelling "Zuko" and MEG experiments. From these results it can be considered that smelling "Zuko" promote the excitation of the higher activities to human brain and make changing the specific brain areas such as OFC, F5 and V1.

**Keywords:** "Zuko" rubbing into the hands, OFC, P300m, alpha-amylase, MEG, spatiotemporal dipole fit, time-varying analysis
