**Acknowledgements**

find larger changes in the brain, for example, from the right area to the left area for subject A5, B1, and B2 and from the left area to right area for subject A2 as shown in **Figure 15**. And we can also find out other larger changes in the brain in the same laterality, for example, from the occipital area to the prefrontal area for subject A3 and from the inferior parietal area to the occipital area for subject A4 at the left side

These above results of larger changes show that the usage of "Zuko" incense rubbing into the hands promote to activate the brain more than smelling incense

This research revealed that smelling "Zuko" incense rubbing into the hands and putting the hands together promoted to excite a few specific brain areas, for example, the orbitofrontal cortex of olfactory area, inner areas of the prefrontal cortex, left language F5 regions, occipital regions of left imaging area V1, and so on in the

A P300 response peak which was known as a kind of ERP responses in brain waves was researched as a response of "cognitive function" by using "oddball

In this MEG experiments, P300m response using "auditory oddball paradigm" was measured both before smelling "Zuko" incense and after smelling "Zuko"

In our experiments, evoked neuronal activity was recorded by the MEG and the alpha-amylase value in the subject's saliva was also measured in the stage before and after smelling "Zuko" incense and measuring the response of MEG in the brain. From the summary of results in 3.5.1-3.5.3 in Section 3.5, we can conclude the distinct activities as follows. Both smelling "Zuko" incense only without putting the hands and smelling "Zuko" incense into the hands with putting the hands promoted to activate mainly a few specific brain areas such as the OFC frontal regions, left inner frontal region F5 language area, left inner occipital regions V1 visual areas,

As a cognitive P300m response, it was shown that the result with smelling "Zuko" had shorter latency time; the bigger the peak height, the larger the active wave area S than without smelling "Zuko." From these typical results of P300m responses, it can be considered that a possibility of improving cognitive ability of P300 peak was shown by smelling "Zuko" incense using "auditory oddball para-

From these typical results of P300m responses, it can be considered that a possibility of improving cognitive ability of P300 peak was shown by smelling

thing stress on smelling "Zuko" incense was usually given to the subject.

An alpha-amylase value was shown as a characteristic index of stress which was more increasing up after smelling "Zuko" incense than before smelling although male/female and habit/no habit with putting the hands in daily life. From these results of measuring alpha-amylase value in saliva, it can be considered that some-

From these results of measuring alpha-amylase value in saliva, it can be considered that something stress on smelling "Zuko" incense was usually given to the

From an individual analysis, we can also find out that subject B5 obtained in orbitofrontal cortex, subject A5 and B4 obtained in the inner frontal area, subject A3, A4, and B2 obtained in the occipital cortex V1 as an estimation active area in the

"Zuko" incense using "auditory oddball paradigm."

in the brain.

*Sino-Nasal and Olfactory System Disorders*

**5. Conclusions**

human brain.

incense.

and so on.

digm."

subject.

**196**

paradigm" experiment.

odor.

We sincerely thank Mr. Kimiyoshi Yoshino and Mr. Masaru Yamamoto in Nippon Kodo Co. Ltd. in Japan for the subject's attendance and the supply of "Zuko" incense powder.

This study was supported by the Awards of Alzheimer's Disease in Osaka-Gas Co. and Grants for Alzheimer's Disease in Osaka Research Association in Japan.
