*3.1.1.4 The response for an "auditory oddball paradigm" with smelling "Zuko" incense rubbing into the hands*

**P300m peak of the cognitive response for a rare auditory stimulation with smelling "Zuko" incense rubbing into the hands.** In this experimental task on an "auditory oddball paradigm," a subject concentrates his attention to the rare auditory pulse stimulation which was given without smelling. A subject must push the optic fiber button quickly when he caught the rare auditory tone.

In this "auditory oddball paradigm," two kinds of auditory pulse stimuli were used (1ch, rare stimulation, 1 kHz tone burst, 2ch, frequent stimulation, 2 kHz tone burst). Two auditory pulse stimuli were given to the subject in the duration of 300 ms pulse tone burst at random intervals which were controlled at the rate of 1:3 for rare stimuli (1 kHz tone): frequent stimuli (2 kHz tone).

We obtained a P300 peak response of the subject's type as an individual variation for the priority of brain laterality regarding for "auditory oddball paradigm" with smelling "Zuko" incense rubbing into the hands.

**Figure 11** shows an example of P300m MEG response to an "auditory oddball paradigm" for a subject B2 with smelling "Zuko" incense into the hands. The active area in the brain was obtained with the single current dipole tracing method for this MEG experimental condition. We analyzed the estimated active areas continuously using a real-time estimation method. **Figure 11a** shows an example of P300m of MEG wave (black wave line) response to "auditory oddball paradigm" for subject B2 with smelling "Zuko" incense into the hands.

**Figure 11b** shows a vector of single current dipole estimated in the brain using 3- D coordinates. In this case, we obtained that active area was at the right anterior temporal area in the brain when he recognized a rare tone at the "auditory oddball paradigm" without smelling "Zuko" incense into the hands.

*Smelling "Zuko": Incense Rubbing into the Hands and Smelling the Hands Activates… DOI: http://dx.doi.org/10.5772/intechopen.88987*

#### **Figure 11.**

equivalent negative magnetic fields on the subject's head surface. A green arrow shows an estimated single current dipole obtained from these contour mapping by

*An example of MEG responses to smelling "Zuko" incense rubbing into the hands and putting the hands together in subject A4. (a) Contour map of equivalent magnetic fields and an estimated current dipole (green arrow) on the head for the smelling "Zuko" incense with putting the hand in subject A4. (b) A vector of single current*

*3.1.1.4 The response for an "auditory oddball paradigm" with smelling "Zuko" incense*

optic fiber button quickly when he caught the rare auditory tone.

for rare stimuli (1 kHz tone): frequent stimuli (2 kHz tone).

with smelling "Zuko" incense rubbing into the hands.

B2 with smelling "Zuko" incense into the hands.

paradigm" without smelling "Zuko" incense into the hands.

**P300m peak of the cognitive response for a rare auditory stimulation with smelling "Zuko" incense rubbing into the hands.** In this experimental task on an "auditory oddball paradigm," a subject concentrates his attention to the rare auditory pulse stimulation which was given without smelling. A subject must push the

In this "auditory oddball paradigm," two kinds of auditory pulse stimuli were used (1ch, rare stimulation, 1 kHz tone burst, 2ch, frequent stimulation, 2 kHz tone burst). Two auditory pulse stimuli were given to the subject in the duration of 300 ms pulse tone burst at random intervals which were controlled at the rate of 1:3

We obtained a P300 peak response of the subject's type as an individual variation for the priority of brain laterality regarding for "auditory oddball paradigm"

**Figure 11** shows an example of P300m MEG response to an "auditory oddball paradigm" for a subject B2 with smelling "Zuko" incense into the hands. The active area in the brain was obtained with the single current dipole tracing method for this MEG experimental condition. We analyzed the estimated active areas continuously using a real-time estimation method. **Figure 11a** shows an example of P300m of MEG wave (black wave line) response to "auditory oddball paradigm" for subject

**Figure 11b** shows a vector of single current dipole estimated in the brain using 3- D coordinates. In this case, we obtained that active area was at the right anterior temporal area in the brain when he recognized a rare tone at the "auditory oddball

the computer.

**186**

**Figure 10.**

*rubbing into the hands*

*Sino-Nasal and Olfactory System Disorders*

*dipole (red line) estimated in the brain using a 3-D coordinates.*

*An example of P300m MEG response for an "auditory oddball paradigm" with smelling "Zuko" incense in subject B2. (a) An example of P300m MEG wave (black wave line) response for an "auditory oddball paradigm" with smelling "Zuko" incense in subject B2. (b) A vector of single current dipole (red line) estimated in the brain using a 3-D coordinates.*

**Figure 11a** shows that the value of the maximum peak height of P300m was 60.4 fT/cm and the size of the peak area was S = 32.0 (fT/cm)<sup>2</sup> as the latency time of P300m at T = 310.5 ms. **Figure 11b** shows that an active area of the cognitive P300m peak of "auditory oddball paradigm" with smelling "Zuko" incense into the hands was at the left superior temporal area in the brain.

**Figure 12** shows also another example of P300m MEG response to an "auditory oddball paradigm" for a male subject B1 with smelling "Zuko" incense into the hands. The active area in the brain was obtained with the single current dipole tracing method for this MEG experimental condition. We analyzed the estimated active areas continuously using a real-time estimation method. **Figure 12a** shows an

#### **Figure 12.**

*An example of P300m MEG response for an "auditory oddball paradigm" with smelling "Zuko" incense in subject B1. (a) An example of P300m MEG wave (black wave line) response for an "auditory oddball paradigm" with smelling "Zuko" incense in subject B1. (b) A vector of single current dipole (red line) estimated in the brain using a 3-D coordinates.*

example of P300m of MEG wave (black wave line) response to "auditory oddball paradigm" for subject B1 with smelling "Zuko" incense into the hands. **Figure 12b** shows a vector of single current dipole estimated in the brain using 3-D coordinates. In this case, we obtained that active area was at the left posterior temporal area in the brain when he recognized a rare tone at the "auditory oddball paradigm" with smelling "Zuko" incense into the hands.

From these estimations of **Figure 12**, it was obtained that the results of a cognitive P300m peak height in the brain was 26.0 ft./cm and the active wave area value of the P300 peak was S = 15.0 (fT/cm)<sup>2</sup> at the time T = 281.4 ms when a rare tone was recognized at "auditory oddball paradigm" with smelling "Zuko" incense in the MEG experiment. And it was also obtained that the cognitive P300 peak was found in left posterior temporal area.
