**4.4 Smelling "Zuko" incense and putting the hands together showed larger changes than smelling incense odor with putting the hands together**

We already have the results of the previous MEG experiments for smelling incense odor with putting the hands together as shown in our paper published in IntechOpen [23]. From these results of previous MEG experiments, it was obtained that smelling incense odor with putting the hands activates few specific brain areas.

On the other hand, in these MEG experiments, it was obtained that the results of smelling "Zuko" incense into the hands and putting the hands promote to excite few same specific brain areas as shown in **Figure 15** in Section 3.4.

From the results of **Tables 1** and **2**, we can find out that subject B5 obtained in orbitofrontal cortex OFC, subject A5, and B4 obtained in inner frontal area, subject A3, A4, and B2 obtained in occipital cortex V1 as an estimation active area in the brain clearly show almost all larger value ofα-amylase after smelling "Zuko" and putting the hands and MEG experiments before these experiments. These results are considered to show something stress by smelling "Zuko" incense and putting the hands for the response of subject A3, A4, B2, B3, B4, and B5 which showed large activity in a few special areas in the brain.

From the comparison with these two experimental results and analysis, we can obtain that smelling "Zuko" incense and putting the hands together showed clearly larger changes than smelling incense odor with putting the hands together. We can

group) and no habit (B-group) of putting the hands in daily life. The larger active effects for smelling "Zuko" incense rubbing into the hands and putting the hands were obtained more than the previous smelling incense odor activity with putting

**4.1 A possibility for improving cognitive ability by smelling "Zuko" incense from the results of P300m responses of "auditory oddball paradigm"**

We try to discuss a possibility for improving cognitive ability by smelling "Zuko" incense from the results of the following examples of P300m responses of

*4.1.1 The comparison of a P300m peak of MEG response with nonsmelling and smelling*

Though the typical examples are the results of P300m MEG responses of only

1.As a cognitive P300m response, it was shown that the result with smelling

2.As a cognitive P300m response, it was shown that the result with smelling

3.As a cognitive P300m response, it was shown that the result with smelling "Zuko" had larger active wave area S than without smelling "Zuko."

From these typical results of P300m responses, it can be considered that a possibility of the improving cognitive ability of P300 peak was shown by smelling

**4.2 Effects of stress on the comparison with before and after smelling "Zuko"**

alpha-amylase value in saliva from the results of **Table 1**, **Figures 13** and **14**. From these results of alpha-amylase value in saliva, it was shown that the

We can find out few effects of stress for smelling "Zuko" incense by measuring

1.This report shows the results of the statistical comparison with habit and no habit with putting the hands by using alpha-amylase value in saliva.

2.We could not find out a significant difference among the sex in 10 Japanese

3.We could not find out a significant difference among the habit and no habit with smelling "Zuko" incense and putting hands together in daily life.

4. In only female subjects, we found out a significant difference (P < 0.079) in Ttests among before and after smelling "Zuko" incense rubbing into the hands.

subjects as the statistical value of alpha-amylase in saliva.

"Zuko" had shorter latency time than without smelling "Zuko."

"Zuko" had bigger peak height than without smelling "Zuko."

the hands from the results of summaries in **Figure 15** in Section 3.4.

"auditory oddball paradigm" MEG experiments.

*Sino-Nasal and Olfactory System Disorders*

two subjects, we can find out the results as follows:

"Zuko" incense using "auditory oddball paradigm."

following discussions were obtained:

**194**

**incense by measuring alpha-amylase value in saliva**

**4. Discussions**

*"Zuko" incense*

find larger changes in the brain, for example, from the right area to the left area for subject A5, B1, and B2 and from the left area to right area for subject A2 as shown in **Figure 15**. And we can also find out other larger changes in the brain in the same laterality, for example, from the occipital area to the prefrontal area for subject A3 and from the inferior parietal area to the occipital area for subject A4 at the left side in the brain.

brain clearly show almost all larger value of alpha-amylase after smelling "Zuko" and putting the hands and MEG experiments before these experiments. These results are considered to show something stress by smelling "Zuko" incense and putting the hands for the response of subjects A3, A4, B2, B3, B4, and B5 which

*Smelling "Zuko": Incense Rubbing into the Hands and Smelling the Hands Activates…*

From the above results, we consider that the F5 language area in the left frontal cortex and V1 visual area were promoted to activate by smelling "Zuko" incense

Alpha-amylase showed something stress like for smelling "Zuko" incense with

We concluded that new specific effects both in smelling "Zuko" incense into the hands and imitating the behavior of putting the hands together can be considered to promote excitation of the higher activities and to make larger changes in the brain

We sincerely thank Mr. Kimiyoshi Yoshino and Mr. Masaru Yamamoto in Nippon Kodo Co. Ltd. in Japan for the subject's attendance and the supply of "Zuko"

This study was supported by the Awards of Alzheimer's Disease in Osaka-Gas Co. and Grants for Alzheimer's Disease in Osaka Research Association in Japan.

Department of Medical Engineering, Faculty of Health Science, Aino University,

© 2019 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium,

\*Address all correspondence to: gah00161@nifty.ne.jp

provided the original work is properly cited.

putting the hands, and the specific mirror neuron and default-mode network

activities dynamically in a few specific regions in the human brain.

showed large activity in a few special areas in the brain.

rubbing into the hands with putting the hands together.

showed activity of the special areas in the brain.

*DOI: http://dx.doi.org/10.5772/intechopen.88987*

**Acknowledgements**

incense powder.

**Author details**

Mitsuo Tonoike

**197**

Ibaraki, Osaka, Japan

These above results of larger changes show that the usage of "Zuko" incense rubbing into the hands promote to activate the brain more than smelling incense odor.
