Meet the editors

Assoc. Prof. Müzeyyen Gönül graduated from Ankara University School of Medicine. Currently, she is Associate Professor in the Department of Dermatology at the Health Science University, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey. She has published approximately 200 articles in international and national journals, three books as editor/ co-editor, and six book chapters. Her research interests are pso-

riasis, urticaria, autoimmune bullous disorders, and Behçet's disease

Arzu Kılıç, MD, is the head of the Department of Dermatology at Balikesir University Medical Faculty. She has been working as a professor at the Dermatology Department in Balikesir University School of Medicine, Balikesir, Turkey, since August 2014. She graduated from Gazi University School of Medicine, Ankara, Turkey, in 2000 and worked as a specialist and associate professor in Numune Education and Research Hospital,

Ankara, Turkey, between 2004 and 2014. Dr. Kılıç has published several articles in more than 80 international, peer-reviewed ISI-JCR journals and more than 60 national journals. She has also published three book chapters and more than 50 conference proceedings. She has also edited one book and has supervised several medical students.

Contents

**Section 1**

**Section 2**

**Section 3**

Genetics of Behçet's Disease *by Xiaodong Zhou and Yan Deng*

*by Yuki Nanke and Shigeru Kotake*

Behçet's Disease and Pregnancy *by Gökçe Işıl Kurmuş and Erol Koç*

**Preface III**

An Overview of Behçet's Disease **1**

**Chapter 1 3**

**Chapter 2 15**

Pathogenesis of Behçet's Disease **35**

**Chapter 3 37**

**Chapter 4 55**

Pregnancy and Behçet's Disease **69**

**Chapter 5 71**

Behçet's Disease: An Enigmatic Malady with Plethoric Expressions

The Role of Th17 Cells in the Pathogenesis of Behçet's Disease

The History and Diagnosis of Behçet's Disease *by Müzeyyen Gönül, Arzu Kılıç and Bilgen Gençler*

*by Shamaz Mohamed and Abhilash R. Krishnan*

## Contents


Preface

Behçet's disease is a chronic, relapsing, inflammatory multisystem disease characterized by oral and genital ulcers, cutaneous lesions, and ocular and articular involvement of unknown etiology. It can also affect the gastrointestinal, cardiovascular, and nervous systems. It can cause severe systemic involvement, morbidity, and even mortality. Genetic factors have been investigated extensively, and have defined new genetic polimorphisms associated with the disease. Research into the immunopathogenesis of Behçet's disease has increased our knowledge of this subject. The diagnosis of Behçet's disease is based on clinical criteria, as there is no pathognomonic test. In Behçet disease, there is a wide variety of mucocutaneous and systemic findings that can be confused with many diseases in differential diagnosis. Therefore, being aware of the disease and recognizing the mucocutaneous symptoms would lead to accurate diagnosis. The aim of this book is to present information to our colleagues in different branches of medicine by discussing the genetic and immunologic etiopathogenesis, clinical features, and relationship with pregnancy of Behçet's disease in five chapters:



about this book.



We believe that this book will be a valuable reference to students, researchers, dermatologists, and other healthcare professionals interested in Behçet's disease. We are very grateful to all the authors for their efforts and patience needed to bring

> **Müzeyyen Gönül, MD** Associate Professor, Health Science University,

> > Dermatology Clinic, Ankara, Turkey

Balıkesir University, Dermatology Department,

**Arzu Kılıç, MD** Professor,

Balıkesir, Turkey

Dışkapı Yıldırım Beyazıt Training and Research Hospital

