**Conflict of interest**

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

**51**

**Author details**

and Yi-Wen Wang3

Shu-Jen Chang1,2, Dewi Sartika2

Center, Taipei, Taiwan, ROC

\*

Medical Center, Taipei, Taiwan, ROC

Medical Center, Taipei, Taiwan, ROC

provided the original work is properly cited.

, Gang-Yi Fan1,2, Juin-Hong Cherng2,3

1 Independent Research Fellow, Tri-Service General Hospital, National Defense

2 Laboratory of Stem Cell and Tissue Regeneration, National Defense Medical

3 Department and Graduate Institute of Biology and Anatomy, National Defense

© 2019 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium,

\*Address all correspondence to: christmas1035@hotmail.com

*Animal Models of Burn Wound Management DOI: http://dx.doi.org/10.5772/intechopen.89188* *Animal Models of Burn Wound Management DOI: http://dx.doi.org/10.5772/intechopen.89188*

*Animal Models in Medicine and Biology*

**5. Conclusion**

burn patients.

**Acknowledgements**

**Conflict of interest**

will give the best correlation to human trials.

for clinical trials in humans with burn injuries. Generally, the choice of animals for burn model is mainly based on cost and ethics and further is based on which species

Several substantial advancements have been made in burn patient care such as controlling wound healing, developing novel graft and coverage preferences, optimizing dietary needs, and testing unique pharmacological interventions, resulting in an improved patient's survival and decreased hospitalization period [11]. For example, Wang et al. established a clinical scar in a pig burn model that is found to greatly correlate with scar histology, wound size, and reepithelialization data [55]. This clinical scar scale demonstrated a reliable and independent tool for assessing the burn wound healing outcomes without using other healing and scar measuring systems. Clinically, scar appearance and function are the major concerns to both burn victims and their carers, so its minimization is one of the ultimate goals of

Burn injury is one of the most severe forms of trauma that is related with significant pain and various physical, psychological, and social diminishments; therefore, the exploration of advanced treatment strategies in order to obviously heal and reduce the lifelong burn wound recovery phases is demanding. Burn animal models have been proposed as valuable tools that provide considerable insights into the burn pathophysiology as well as for investigating the properties of new medicines before the clinical use. Accordingly, the standardization of animal models is crucial for all scientific research, and it can merely be achieved with a comprehensive description of the experimental techniques along with their advantages and limitations. With a better understanding of burn underlying phenomenon as animal models paved the road to its mechanisms, progressive research is expected to continuously identify novel treatment strategies to improve the quality of life for

The authors would like to thank Prof. Jiang-Chuan Liu and Prof. Nien-Hsien Liou (Department and Graduate Institute of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan (ROC)) for the knowledge and moral support and also Dr. Chih-Hsin Wang (Department of Plastic and Reconstructive Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei,

The authors declared no potential conflicts of interest with respect to the

Taiwan (ROC)) for his helpful discussion during this chapter writing.

research, authorship, and/or publication of this article.

burn care, which relies on the appropriate evaluation of the scars.

**50**
