**Abstract**

Burn injury is known as the most traumatic wound. In the clinical, most patients with burn injury suffer from extreme pain during wound management; hence, the effective treatment that involved advanced medication is needed. In the evaluation of burn wound care devices, the use of animal model is considered suitable as valuable tools to investigate the burn pathophysiology as well as the efficacy of treatment strategies due to the complexity and heterogeneous nature of the burn. This chapter aimed to review the preclinical small and large animal models of burn injury for translational applications and to highlight their benefits and limitations for the burn treatment design that are clinically applicable to humans.

**Keywords:** burn wound, treatment, animal model
