**Abstract**

Nanoadditives are a type of heat transfer enhancement techniques adopted in heat exchangers to improve the performance of industrial plants through improvement of the thermal properties of base fluids. Recently, various types of inserts with nanofluids are adopted to enhance the thermal performance of double pipe heat exchangers. In the current article, TiO2/water nanofluid with multiple twisted tape inserts was investigated as a hybrid enhancement technique of heat transfer in straight pipes. The investigations were carried out experimentally and numerically at Reynolds numbers varied from 5000 to 20,000. Using nanofluid with 0.1% TiO2 nanoparticles volume fraction demonstrated enhanced heat transfer with slight increase in pressure drop. Results are showing a maximum increase of 110.8% in Nusselt number in a tube fitted with quintuple twisted tape inserts with 25.2% increase in the pressure drop. However, as the article is representing a part of specified book on heat exchangers, the literature has been extended to provide sufficient background to the reader on the use of nanotech, twisted inserts, and hybrid of compound nanofluids and inserts to enhance heat transfer processes.

**Keywords:** enhanced heat transfer, hybrid heat transfer enhancement, multi-longitudinal vortices, multiple twisted tapes, TiO2 nanofluid
