We are IntechOpen, the world's leading publisher of Open Access books Built by scientists, for scientists

4,100+

Open access books available

116,000+

International authors and editors

120M+

Downloads

Our authors are among the

Top 1%

most cited scientists

12.2%

Contributors from top 500 universities

Selection of our books indexed in the Book Citation Index in Web of Science™ Core Collection (BKCI)

## Interested in publishing with us? Contact book.department@intechopen.com

Numbers displayed above are based on latest data collected. For more information visit www.intechopen.com

## Meet the editors

Dr. Muharrem Ince received his PhD degree in Analytical Chemistry at Firat University, Turkey, in 2008. He worked at Mus Alparslan University, Turkey, from 2009 to 2012 as an assistant professor. He has been working at Munzur University since 2012. From 2013 to 2016, he served as Head of Department of Chemical Engineering at Munzur University. He is an editorial board member of several international journals. Currently, he is

an associate professor at Munzur University. He is the author and coauthor of more than 25 papers published in respectable international journals. He is an expert on analytical method development, spectroscopic and chromatographic techniques, trace element analysis, food analysis, and toxicology.

Dr. Olcay Kaplan Ince received her BS degree from Hacettepe University and her PhD degree in Analytical Chemistry from Firat University in Turkey in 2008. She has been a research analytical chemist at Munzur University since 2009 in the Food Engineering Department. She was also Head of Department of Food Engineering at Munzur University, 2014–2015. She has been serving as an associate editor of the *International Journal of* 

*Pure and Applied Sciences* since 2015. She is the author of more than 28 papers published in journals with good impact factors in their area. Her research areas include atomic absorption spectroscopy, speciation, trace and toxic element analysis, analytical chemistry, instrumental analysis, problem solving in analytical chemistry, food science, and chromatography, especially high-performance liquid chromatography-mass spectrometry and gas chromatography.

**Preface III**

Sample Preparation Techniques **1**

**Chapter 1 3**

Analytical Instrumentation and Methods **21**

**Chapter 2 23**

**Chapter 3 45**

**Chapter 4 65**

Separation Approaches and Validation **95**

**Chapter 5 97**

*by Claudia Nelson, Raymond Bacala, Baylie Gigolyk, Evelyn Ang, Haley Neustaeter,* 

Quantitative and Qualitative LC-High-Resolution MS: The Technological

Modern Extraction and Cleanup Methods of Veterinary Drug Residues in

Contribution of Infrared Spectroscopy to the Vibrational Study of Ethylenediammonium Chloride Thiocyanate: (C2H10N2)(Cl NCS)

Characterization of Whole and Fragmented Wild-Type Porcine IgG

*Emy Komatsu, Oleg Krokhin, Dave Hatcher and Hélène Perreault*

Bioanalytical Method Development and Validation: A Review

*by Mahesh Mukund Deshpande, Veena Sanjay Kasture, Mahalaxmi Mohan* 

and Biological Reasons for a Shift of Paradigm

*by Babra Moyo and Nikita Tawanda Tavengwa*

*by Sahel Karoui and Slaheddine Kamoun*

**Section 1**

**Section 2**

**Section 3**

*and Macchindra J. Chavan*

*by Bertrand Rochat*

Contents

Food Samples of Animal Origin

## Contents



Preface

This book presents recent and future trends in analytical methods and provides an overview of analytical chemistry, organized into four sections. As a comprehensive analytical chemistry book, it takes a broad view of the subject and integrates a wide variety of approaches. The first section of the book discusses sample preparation techniques. Topics include analytical instrumentation and methods, separation approaches and validation, and recent developments and applications in analytical chemistry. The book was written primarily for researchers in the fields of analytical chemistry, environmental chemistry, food and chemical engineering, and applied chemistry. Its aim is to explain the subject, clarify important studies, and compare and develop new and groundbreaking applications. Written by leading experts in their respective areas, it is highly recommended for professionals who are interested in analytical chemistry because it provides specific and comprehensive examples that compare new and classical methods. The book is edited by Dr. Muharrem Ince

from Munzur University, Turkey. I hope the readers will find it useful.

**Muharrem Ince and Olcay Kaplan Ince**

Munzur University, Tunceli, Turkey
