**1. Introduction**

Cancer is the major cause of mortality in economically advanced nations, and in developing nations it is the second leading cause of death [1]. The survival rate due to the heterogeneity in treatment offered within centers across India for buccal mucosa cancer in India is 5 years ranges from 60 to 80% for stage I disease to 5 to 15% for locally progressive disease [2, 3].

Squamous cell carcinoma (HNSCC) develops in the oral cavity, larynx, or hypopharynx and oropharynx. In accordance with incidence rate, it is reported as the sixth leading cancer worldwide [4]. It is likely that approximately 600,000 cases have been established worldwide, and the 5-year survival rate is only 40–50% in patients with HNSCC [5]. In a 5-year period, estimated new cases of head and neck cancer were 300,000 and approximately 145,000 deaths in 2012 and 702,000 predominant cases [6]. It was reported that two-thirds of the global incidence of oral cancer occurs in low- and middle-income countries (LMICs). In that, half of those cases are in South Asia. In India alone, one-fifth of the population have head and neck cancer and one-fourth of all head and neck cancer demises [6]. **Figure 1** illustrates the region of all head and neck cancers.
