**12. Mechanism of myocardiopathy in obesity**

Insulin resistance, adiposity, and adipokines have been implicated in the development of abnormal myocardial mechanics in adults with obesity and type 2 diabetes. Adiposopathy in obese individuals is ultimately the consequence of a dysfunctional remodeling of the adipose tissue. Therefore, for understanding how obesity contributes to cardiovascular disease, it is primordial to know how both quantitative and qualitative effects of this adipose tissue remodeling contribute to that.
