**1.6 ω fatty acid receptor**

GPR120 is proposed to function as an ω-3 FA receptor/sensor in pro-inflammatory macrophages and mature adipocytes. By signaling through GPR120, DHA and EPA mediate potent anti-inflammatory effects to inhibit both TLR (toll-like receptor) and TNF-α inflammatory signaling pathways [32].

DHA and EPA stimulate GRP 120 and cause a decrease of glucose uptake by adipocytes, inhibit inflammation by macrophages, secrete glucagon-like peptide 1 (GLP-1), and increase insulin secretion by pancreas (**Figure 4**).

These data suggest that DHA and EPA may be effective for prevention and treatment of cardiovascular disease and diabetes mellitus.
