*5.2.2.3 Caveolin-mediated endocytosis*

Caveolin-mediated endocytosis which starts with a flask-shaped pit in a cavelike membrane is a specific uptake of extracellular molecules. The CPP with its cargo is bound to the membrane, trapped in caveolae which are linked to actinic cytoskeletal elements, and then a protein tyrosine phosphorylation and actin depolymerization are supported. Dynamin is the type of a GTPase liable for endocytosis in the eukaryotic cells that define other actin polymerization on the patch. Finally, cargo-loaded pouches are released inside the cytosol [106]. The various endocytic paths mentioned above have disadvantages such as low specificity, high dependence on the cell line used, and decreased cell viability [96, 107].
