Poly(L-Lactide) Bionanocomposites

*Ali Nabipour Chakoli*

## **Abstract**

A variety of natural, synthetic, and biosynthetic polymers such as poly(L-lactide), polyhydroxyalkanoate, and poly(ε-caprolactone) are biocompatible and environmentally degradable. Biodegradability can therefore be engineered into polymers by the judicious addition of chemical linkages such as anhydride, ester, or amide bonds, among others. Poly(L-lactide) (PLLA) has attracted increasing attention due to the combination of its bioresorbability, biodegradability, biocompatibility, and shape memory effect. It has been widely applied to biomedical fields such as bone screws, surgical sutures, tissue engineering, and controlled drug delivery. Nevertheless, the PLLA is weaker than that of natural cortical bones in mechanical strength. Additionally, the ability of PLLA in cell attachment and bioactivity are weak due to its hydrophobic properties. In order to overcome the unsuitable properties of PLLA, various techniques have already been applied to modify the physical and mechanical properties of PLLA. The most significant method is to introduce some various kinds of fillers into PLLA matrix to provide reinforcing filler/PLLA composites, such as hydroxyapatite (HA), b-tricalcium phosphate, bioglass, silica gel, amorphous carbon, carbon nanotubes (CNTs), and so on.

**Keywords:** poly(L-lactide), nanocomposites, nanomaterials, tissue engineering
