**Acknowledgements**

The study was financially supported by grants from the research council of the University of Hong Kong (Project Codes: 104004092, 104004460, 104004746); the Research Grants Committee (RGC) of Hong Kong, HKSAR (Project Codes: 764708, 766211, 17152116); Wong's Donation on Modern Oncology of Chinese Medicine (Project code: 200006276); Gala Family Trust (Project Code: 200007008); and Innovation Technology Fund of Hong Kong (ITF. Project code: 260900263).
