**Abstract**

The Pandemic of COVID-19 has been thoroughly followed and discussed on many levels due to the high level of attention that it has brought by its effect on the world. While this disease might seem like to arise out of the blue, we will shed light on COVID-19 disease which is caused by the virus SARS-CoV2 and belong to family of coronaviruses. We will discuss current knowledge about SARS-CoV2 emergence, diagnosis, its mode of action, and genomic information, For an antiviral treatment to be used, it should be preceded by a foundation of information about the virus genome and its family as discussed in this review.

**Keywords:** Covid-19, SARS-COV-2, genome, evolution, immunopathology, phylogenetic
