**Abstract**

Parallel to *Plasmodium falciparum*, *P. vivax* is a fast emerging challenge to control malaria in South-East Asia regions. Owing to unique biological differences such as the preference for invading reticulocytes, early maturation of sexual stages during the infection, the formation of hypnozoites, unavailability of *in-vitro* culture, the molecular relation of *P. vivax* development inside the mosquito host is poorly known. In this chapter, we briefly provide a basic overview of Mosquito-*Plasmodium* interaction and update current knowledge of tissue-specific viz. midgut, hemocyte, and salivary glands- molecular dynamics of *Plasmodium vivax* interaction during its developmental transformation inside the mosquito host, in specific.

**Keywords:** malaria, mosquito, *Anopheles*, *Plasmodium vivax*, host–parasite interaction
