**16. Magnisum sulphate for neuroprotection**

Children born to women given magnesium sulphate for seizure prevention in severe pre-eclampsia were noted to have lower rates of cerebral palsy. This is possibly because magnisum decreases extracellular glutamate with hypoxia and hence reduces excitotoxicity. It also limits calcium influx through voltage-gated channels and in turn reduces the activation of apoptosis. Further more it reduces oxidative stress and reduces the production of pro-inflammatory cytokines.

It is use for neuroprotection is recommeded for use in women with established preterm labour or planned to hace elective preterm birth within 24 hours at gestations between 24 and 30 weeks. It is can be considered between 30 and 34 weeks [1, 23].
