Meet the editors

Dr. Ana Gil de Bona received her PhD in Microbiology and Proteomics from Complutense University of Madrid, Spain. Her research mainly focused on the study of the proteomic profile of extracellular vesicles and the secretome in virulent and avirulent strains of *Candida albicans*. She continued her scientific carrier at the University of Massachusetts Medical School working on yeast genetics and proteomics. Her current research at the

Forsyth Institute affiliated with Harvard School of Dental Medicine is focused on understanding how the organic matrix composition of enamel is affected by the oral environment in healthy and defective teeth. She has authored peer-reviewed research articles, reviews, and has presented her work to national and international scientific meetings.

Dr. Jose Antonio Reales Calderon received his PhD in Microbiology/Immunology at the Complutense University of Madrid, Spain. During the PhD he performed a proteomic/phosphoproteomic study of the response of macrophages to *Candida albicans*. He has also enjoyed two different short stays, one at the University of Southern Denmark (Odense, Denmark) and one at MIT (Massachusetts, USA). After this, he obtained a postdoctor-

al position in a research network aimed at improving and developing high-quality basic, translational, and clinical research in the area of clinical microbiology and infectious diseases (Spanish Network for Research in Infectious Diseases). Currently, he is a senior research fellow at the Singapore Immunology Network (A\*STAR) in Singapore. His current position allows him to study a booster of the innate immunity to protect against systemic infections.

Contents

**Section 1**

of Use

**Section 2**

**Section 3**

*and Nathan R. Wall*

Metabolizing Enzymes *by Dino G. Salinas*

Extracellular Vesicles in Cancer

**Preface III**

Introduction to the Extracellular Vesicles **1**

**Chapter 1 3**

**Chapter 2 11**

The Biology of Extracellular Vesicles **39**

**Chapter 3 41**

**Chapter 4 71**

Extracellular Vesicles in Human Diseases **87**

**Chapter 5 89**

Introductory Chapter: An Overview to the Extracellular Vesicles

*by Sergey E. Sedykh, Evgeniya E. Burkova, Lada V. Purvinsh, Daria A. Klemeshova, Elena I. Ryabchikova and Georgy A. Nevinsky*

Milk Exosomes: Isolation, Biochemistry, Morphology, and Perspectives

Cellular-Defined Microenvironmental Internalization of Exosomes *by Amber Gonda, Ron Moyron, Janviere Kabagwira, Paul A. Vallejos* 

Effects of Vesicular Membranes Reordering on the Activity of Lipid

*by Andrei-Dennis Voichitoiu, Beatrice Mihaela Radu, Luciana Pavelescu, Dragos Cretoiu, Antonia Teona Deftu, Nicolae Suciu and Sanda Maria Cretoiu*

*by Ana Gil-Bona and Jose Antonio Reales-Calderon*
