**15. Conclusions**

In present review we focus on evidence to prevent neurodegenerative disorders in various studies (*in vitro* and *in vivo*). The mentioned medicinal plants play their protective roles *via* increased SOD and catalase levels, restoration of GSH, and decreased MDA levels and also protect neurons against ROS as antioxidant activities. The neuroprotective effects of the mentioned plants occur *via* reduction of inflammatory cytokines as well as enhancement of anti-inflammatory cytokines, inhibition of the acetylcholinesterase activity, and decreased MDA levels in the neural system via modulating GABAergic and glutamatergic neurons and also increasing amount of amino acids and serotonin (5-HT) in the neurotransmitters systems. Based on the evidence produced, it is suggested that more exploration of traditional formulations is required, and also repurposing in natural products is also required to a greater extent, as is evident from recent reports on garcinol and berberine.
