*Opium Alkaloids DOI: http://dx.doi.org/10.5772/intechopen.91326*

receptors belong to a family of receptors that are coupled to potassium channels. Proceedings of the National Academy of Sciences of the United States of America. 1987;**84**:5487-5491. DOI: 10.1073/pnas.84.15.5487

[44] Malaivijitnond S, Varavudhi P. Evidence for morphine-induced galactorrhea in male cynomolgus monkeys. Journal of Medical Primatology. 1998;**27**:1-9. DOI: 10.1111/ j.1600-0684.1998.tb00061.x

[45] Eddy NB, Halbach H, Isbell H, Seevers MH. Drug dependence: Its significance and characteristics. Bulletin of the World Health Organization. 1965; **32**:721-733

[46] Koob GF, Le Moal M. Opioids. In: Neurobiology of Addiction. London: Academic Press; 2006. pp. 121-171

[47] American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Fifth Edition (DSM-5). Arlington: American Psychiatric Association; 2013. pp. 541-546

[48] World Drug Report. New York: United Nations Office on Drugs and Crime; 2012. p. 1

[49] Koob GF. Drugs of abuse: Anatomy, pharmacology and function of reward pathways. Trends in Pharmacological Sciences. 1992;**13**:177-184. DOI: 10.1016/ 0165-6147(92)90060-j

[50] Koob GF, Volkow ND. Neurocircuitry of addiction. Neuropsychopharmacology. 2010;**35**: 217-238. DOI: 10.1038/npp.2009.110

[51] Gómez-Milanés I, Almela P, García-Carmona JA, García-Gutiérrez MS, Aracil-Fernández A, Manzanares J, et al. Accumbal dopamine, noradrenaline and serotonin activity after naloxoneconditioned place aversion in morphinedependent mice. Neurochemistry International. 2012;**61**:433-440. DOI: 10.1016/j.neuint.2012.06.011

[52] Diana M, Pistis M, Muntoni A, Gessa G. Profound decrease of mesolimbic dopaminergic neuronal activity in morphine withdrawn rats. The Journal of Pharmacology and Experimental Therapeutics. 1995;**272**: 781-785

[53] Yananli H, Gören MZ, Berkman K, Aricioğlu F. Effect of agmatine on brain L-citrulline production during morphine withdrawal in rats: A microdialysis study in nucleus accumbens. Brain Research. 2007;**1132**:51-58. DOI: 10.1016/j.brainres.2006. 11.028

[54] Topkara B, Yananli HR, Sakallı E, Demirkapu MJ. Effects of injection of gamma-aminobutyric acid agonists into the nucleus accumbens on naloxoneinduced morphine withdrawal. Pharmacology. 2017;**100**:131-138. DOI: 10.1159/000477548

[55] Jafarova Demirkapu M, Yananli HR, Kaleli M, Sakalli HE, Gören MZ, Topkara B. The role of adenosine A1 receptors in the nucleus accumbens during morphine withdrawal. Clinical and Experimental Pharmacology & Physiology. DOI: 10.1111/1440-1681. 13224

[56] Chou R, Fanciullo GJ, Fine PG, Adler JA, Ballantyne JC, Davies P, et al. Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain. The Journal of Pain. 2009;**10**: 113-130. DOI: 10.1016/j.jpain.2008. 10.008

[57] Masood AR, Thomas SH. Systemic absorption of nebulized morphine compared with oral morphine in healthy subjects. British Journal of Clinical Pharmacology. 1996;**41**:250-252. DOI: 10.1111/j.1365-2125.1996.tb00192.x

[58] Hunt A, Joel S, Dick G, Goldman A. Population pharmacokinetics of oral morphine and its glucuronides in children receiving morphine as immediate-release liquid or sustainedrelease tablets for cancer pain. The Journal of Pediatrics. 1999;**135**:47-55. DOI: 10.1016/s0022-3476(99)70326-4

[59] Christrup LL. Morphine metabolites. Acta Anaesthesiologica Scandinavica. 1997;**41**:116-122. DOI: 10.1111/j.1399-6576.1997.tb04625.x

[60] Harvey AL. Natural and Synthetic Neurotoxins. London, England: Academic Press; 1993. p. 263

[61] Gossel TA. In: Gossel TA, Bricker JD, editors. Principles of Clinical Toxicology. 3rd ed. New York: CRC Press; 1994. p. 421

[62] Brennan MJ. The effect of opioid therapy on endocrine function. The American Journal of Medicine. 2013; **126**:S12-S18. DOI: 10.1016/j. amjmed.2012.12.001

[63] Broussard CS, Rasmussen SA, Reefhuis J, Friedman JM, Jann MW, Riehle-Colarusso T, Honein MA; National Birth Defects Prevention Study. Maternal treatment with opioid analgesics and risk for birth defects. American Journal of Obstetrics and Gynecology. 2011;**204**:314.e1-11. DOI: 10.1016/j.ajog.2010.12.039

[64] Schmid M, Kuessel L, Klein K, Metz V, Fischer G, Krampl-Bettelheim E. First-trimester fetal heart rate in mothers with opioid addiction. Addiction. 2010;**105**:1265-1268. DOI: 10.1111/j.1360-0443.2010.02982.x

[65] Kopecky EA, Ryan ML, Barrett JF, Seaward PG, Ryan G, Koren G, et al. Fetal response to maternally administered morphine. American Journal of Obstetrics and Gynecology. 2000;**183**:424-430. DOI: 10.1067/ mob.2000.105746

[66] Cobrınık RW, Hood RT Jr, Chusıd E. The effect of maternal narcotic addiction on the newborn infant; review of literature and report of 22 cases. Pediatrics. 1959;**24**:288-304

[67] Dow K, Ordean A, Murphy-Oikonen J, Pereira J, Koren G, Roukema H, et al. Neonatal abstinence syndrome clinical practice guidelines for Ontario. Journal of Population Therapeutics and Clinical Pharmacology. 2012;**19**:e488-e506

[68] Hudak ML, Tan RC, Committee On Drugs, Commıttee on Fetus and Newborn, American Academy of Pediatrics. Neonatal drug withdrawal. Pediatrics. 2012;**129**:e540-e560. DOI: 10.1542/peds.2011-3212

[69] Baka NE, Bayoumeu F, Boutroy MJ, Laxenaire MC. Colostrum morphine concentrations during postcesarean intravenous patient-controlled analgesia. Anesthesia and Analgesia. 2002;**94**:184-187. DOI: 10.1097/ 00000539-200201000-00035

[70] Feilberg VL, Rosenborg D, Broen Christensen C, Mogensen JV. Excretion of morphine in human breast milk. Acta Anaesthesiologica Scandinavica. 1989; **33**:426-428. DOI: 10.1111/j.1399-6576. 1989.tb02938.x

[71] Wittels B, Scott DT, Sinatra RS. Exogenous opioids in human breast milk and acute neonatal neurobehavior: A preliminary study. Anesthesiology. 1990;**73**:864-869. DOI: 10.1097/ 00000542-199011000-00012

[72] Martin E, Vickers B, Landau R, Reece-Stremtan S. ABM clinical protocol #28, peripartum analgesia and anesthesia for the breastfeeding mother. Breastfeeding Medicine. 2018;**13**: 164-171. DOI: 10.1089/bfm.2018. 29087.ejm

[73] Willette RE. Analgesic agents. In: Delgado JN, Remers WA, editors. Textbook of Organic Medicinal and Pharmaceutical Chemistry. 10th ed.
