**6.9 Adiponectin**

In the case of early-onset PE, adiponectin levels are higher than in the first trimester compared to normal controls. This does not apply to late-onset PE. There is no relationship between adiponectin and PAPP-A levels and Doppler values. In addition, there is no advantage in prediction by the addition of adiponectin [75].

### **6.10 Resistin**

Resistin levels in the first trimester are higher in patients who develop preeclampsia than controls. There is no relationship to impaired placental perfusion [75].

#### **6.11 l-Arginine, asymmetric dimethylarginine (ADMA), and homoarginine**

All three substances are part of NO metabolism. l-Arginine and l-homoarginine are increased in the first trimester at later-developing early-onset preeclampsia, as well as the ratio of ADMA/l-arginine and ADMA/L-homoarginine. This is not the case for late-onset preeclampsia and for the isolated analysis of ADMA [76].
