Meet the editors

Marwa Zakaria is an active member in SIOP, EHA and HAA. His professional training and workshops include ICH GCP, EHA-master class and bite size master class. He has received training from Wilkins-Barrick Society of Neurooncology (SNO), Morocco and Training Program in Pediatric Nutrition (School of Medicine Boston University 2017). He was awarded the International Preceptorship in thalassemia (Beirut, September 2015).

His international scholarships and awards include SIOP Scholarship, EHA-HOPE in 2017 and 2018 respectively. He has been the guest speaker at numerous pediatric oncology and hematology meetings and had over 20 international research publications in the field of pediatrics. He is the chief editor of two online books and author of four online book chapters. He is the reviewer for international and national peer-reviewed journals (Medicine (Baltimore), IntechOpen Publisher, Frontiers in Pediatrics, Molecular Medicine Reports, and Zagazig University Medical Journal). He is the sub-investigator in 7 international trials.

An active member at EHA, SIOP, and HAA, Tamer Hassan has had over 50 international research publications in Pediatrics. He has authored four online book chapters and been the coeditor of two online books. His professional training and workshops include ICH GCP online Training, training in 10th international educational course on thalassemia, Cyprus 2006, training in pediatric stem cell transplantation unit in Ulm University, completion of

EHA master class and bite size master class 2016 and 2017 respectively. He has been awarded many international scholarships including SIOP, EHA-HOPE, Hemophilia Preceptorship in Saint Luc Hospital, Belgium, ITP Preceptorship in Dmitry Rogachev National Research Center, Moscow. He is an academic editor for the Medicine (Baltimore) Journal and a reviewer for many international journals (Hemophilia, Medicine, Oncology Letters, Child Neurology). He is the primary investigator in 3 international clinical trials and sub-investigator in 12 international trials.

Contents

**Section 1**

**Section 2**

Updates in Thalassemia

with Iron Overload

**Section 3**

*by Mark D. Scott*

*by Nadia Maria Sposi*

*and Somdet Srichairatanakool*

Introductory Chapter: β-Thalassemia *by Marwa Zakaria and Tamer Hassan*

*by Tamer Hassan and Marwa Zakaria*

Therapeutic Targets in Beta-Thalassemia

*by Pimpisid Koonyosying, Suthat Fucharoen* 

Transcriptional Repressors of Fetal Globin Genes as Novel

Nutraceutical Benefits of Green Tea in Beta-Thalassemia

*by Marianna De Martino, Raffaele Sessa, Maria Rosaria Storino, Mariarosaria Giuliano, Silvia Trombetti, Rosa Catapano, Alessandra Lo Bianco, Paola Izzo and Michela Grosso*

Model Human β Thalassemic Erythrocytes: Effect of Unpaired Purified α-Hemoglobin Chains on Normal Erythrocytes

Oxidative Stress and Iron Overload in β-Thalassemia: An Overview

**Preface XI**

Introduction to Beta Thalassemia **1**

**Chapter 1 3**

Updates in Beta Thalassemia **13**

**Chapter 2 15**

**Chapter 3 25**

**Chapter 4 39**

Pathophysiology of Beta Thalassemia **67**

**Chapter 5 69**

**Chapter 6 91**
