**Abstract**

The lining of the Vater papilla represents a complex set of folds of the mucous membrane which acts as an anti-reflux valve and participates in regulating the flow in pancreatic and biliary secretion. The constitutive smooth muscles of the Oddi sphincter differ both anatomically and especially embryologically from the parietal duodenal muscles. This is one of the reasons why some authors believe that the vaterian ampulloma is a distinct oncologic entity from the rest of the duodenal or pancreatic primitive neoplasia. The variations of the implantation manner in the papilla of the common bile duct and pancreatic one simultaneously determine different ways of surgical approach of malignancies of this region. Radioimaging diagnostic methods in suspected vaterian ampulloma require a more special technique. The purpose of this paper is to determine the potential semiological, radiological, and imaging characteristics that will allow a diagnosis of vaterian ampulloma, considering that the surgical therapy, as well as the survival rate in patients, is different from the other neoplasm of the region.

**Keywords:** vaterian ampulloma, duodenum, barium meal, duodenography, computed tomography, MRI, vaterian ampulloma
