**4. Conclusion**

While much progress has been made to understand A-T at the molecular level, there are still important questions that remain unanswered. This is especially true for the cerebellar neurodegeneration observed in A-T patients, where unknown tissuespecific factors may be at play. The genesis and the extent of some of the A-T clinical features are likely to be the result of interwoven relationships between many pathways and pathologies described in here and hence, elucidating their connections will be crucial to fully understand the disease and develop effective tools for its treatment.
