Scope of the Series

Modern physiology requires a comprehensive understanding of the integration of tissues and organs throughout the mammalian body, including the expression, structure, and function of molecular and cellular components. While a daunting task, learning is facilitated by our identification of common, effective signaling pathways employed by nature to sustain life. As a main example, the cellular interplay between intracellular Ca2 increases and changes in plasma membrane potential is integral to coordinating blood flow, governing the exocytosis of neurotransmitters and modulating genetic expression. Further, in this manner, understanding the systemic interplay between the cardiovascular and nervous systems has now become more important than ever as human populations age and mechanisms of cellular oxidative signaling are utilized for sustaining life. Altogether, physiological research enables our identification of clear and precise points of transition from health to development of multi-morbidity during the inevitable aging process (e.g.,

diabetes, hypertension, chronic kidney disease, heart failure, age-related macular degeneration; cancer). With consideration of all organ systems (e.g., brain, heart, lung, liver; gut, kidney, eye) and the interactions thereof, this Physiology Series will address aims of resolve (1) Aging physiology and progress of chronic diseases (2) Examination of key cellular pathways as they relate to calcium, oxidative stress, and electrical signaling & (3) how changes in plasma membrane produced by lipid peroxidation products affects aging physiology

Contents

**Section 1**

**Section 2**

**Section 3**

**Section 4**

Epilepsy and Cerebral Palsy

*and Ali A. Asadi-Pooya*

*by Albert Ribes-Zamora*

*by Bobbie Jean Koen*

*by Michael Fitzgerald*

*by Marwa Mahmoud Saleh and Aya Adel*

Schizophrenia: Early Recognition and Prevention

**Preface III**

The Future of Psychiatry is Neurodevelopmental **1**

**Chapter 1 3** The Future of Psychiatry and Neurodevelopmental Disorders: A Paradigm Shift

Autism and Schizophrenia **17**

**Chapter 2 19**

**Chapter 3 31**

Epilepsy, Cerebral Palsy and Ataxia **49**

**Chapter 4 51**

**Chapter 5 69**

Reading and Neurodevelopmental Disorder **87**

**Chapter 6 89**

The Role of the DNA Damage Response in Ataxia-Telangiectasia Syndrome

Autism: A Neurodevelopmental Disorder and a Stratum for Comorbidities

*by Delia Marina Podea, Romina Teodora Moldovan and Laura Cristina Popa*

*by Boulenouar Mesraoua, Musab Ali, Dirk Deleu, Hassan Al Hail, Gayane Melikyan, Naim Haddad, Osama Alalamy, Covanis Athanasios* 

The Neurobiological Development of Reading Fluency
