**Acknowledgements**

This research was supported by the Spanish Ministerio de Ciencia, Innovación y Universidades (Grants CTM 2010-12134-E/ANT and CTM2011-16003-E) and the Institute of Health Carlos III (Grant PI14/00705). E.G.L. is a recipient of a Ciencia, Innovación y Universidades Fellowship (Grant PTA2016-12325-I, Programa Nacional de Contratación e Incorporación de RRHH). We thank Paula Alcazar for reading this manuscript and for her helpful suggestions and revisions.
